Additional Clarification on Updated Guidelines on the Preparation, Storage and Expiration of Injectable Medications

September 27, 2017

FAQs on Guidelines on the Preparation, Storage and Expiration of Injectable Medications icon We have received several questions about how the recently updated Guidelines on the Preparation, Storage and Expiration of Injectable Medications apply to specific medications, use cases, and various laboratory scenarios.

In an effort to provide additional clarification, we have compiled a list of the most frequently asked questions below:

Who is affected by these changes?

The guidelines were updated to clarify expectations for the preparation, storage, and use of diluted or mixed injectable drugs. These changes are especially important for labs that mix anesthetics such as ketamine/xylazine, or dilute analgesics such as carprofen, meloxicam, or buprenorphine.

What is required for diluted or mixed anesthetics and analgesics that are injected into animals?

These substances must be:

  • Made, stored, and accessed aseptically
  • Stored in a sterile glass vial with a rubber stopper and labeled with drug(s), concentration(s), and beyond use date
  • Storage can be at room temperature, refrigerated, or you may choose to freeze aliquots. Note that if you refrigerate or freeze controlled substances, they must be appropriately secured
  • The beyond use date (expiration date) is 7 days after diluting or mixing. If you freeze aliquots immediately after mixing or diluting, the 7-day expiration period begins upon thawing the aliquot

What if my lab injects animals with sterile fluids and no added drugs?

  • Fluids injected via IV expire 24 hours after opening the vial or bag
  • Fluids used by other routes, such as subcutaneous fluids, may be utilized for up to 30 days after opening
  • Label the sterile fluid bag or vial with the date when first accessed

If you have specific questions that have not been addressed here, or would like additional clarification on any aspect of the guidelines, please contact your ULAM Faculty Veterinarian. If you don’t know your faculty veterinarian, send an inquiry to ulam-questions@umich.edu and your question will be routed appropriately.