Our Impact

Senior study author Jolanta Grembecka, Ph.D., left, with co-first author Hongzhi Miao, M.S. Photo by Leisa Thompson
Monday, March 2, 2020 Anti-Leukemia Compound Induces Complete Remission in Mouse Models
An anti-cancer compound developed at the University of Michigan has shown “profound” activity in mouse models against two subtypes of leukemia — representing up to 40% of patients — a U-M research team reports in the Journal of Clinical Investigation. A Phase I clinical trial, using a structurally related analog of the compound, also began enrolling patients in the fall of 2019.
Husbandry technician holds white mouse in germ-free facility
Friday, December 13, 2019 Germ-Free Mice May Hold New Clues for Better Treatment of Iron-Related Disorders
In a study involving germ-free mice, Michigan Medicine researchers have unlocked a mechanism behind how the body decides whether or not to absorb iron from the food–one that involves the trillions of bacteria in our guts known as the gut microbiome. What these intriguing findings suggest is an unconventional treatment for iron-related disorders, such as anemia.
A potent and selective degrader of the transcription factor STAT3 offers a new approach to a previously “undruggable” target.
Friday, November 15, 2019 U-M Compound Achieves Lasting Tumor Regression of Leukemia and Lymphoma in Mouse Models
A potent and selective degrader of the transcription factor STAT3 offers a new approach to a previously “undruggable” target. In a mouse model of leukemia, the degrader eliminated all of the tumors, with the mice remaining tumor-free for 60 days. In two mouse models of lymphoma, the drug eliminated all of the tumors for more than 100 days.
White mouse climbs over bedding into clear enrichment tunnel
Friday, November 1, 2019 Discovery in Mice Could Remove Roadblock to More Insulin Production
New research published in Nature Immunology shows that a combination of two immune-system factors could open up new avenues for treating Type 1 and Type 2 diabetes and obesity.
U-M researchers studying prostate cancer cell lines
Monday, October 21, 2019 U-M-Designed Compounds Show Promise in Lab, Mouse Models of Advanced Prostate Cancer
In a new study involving mouse models and prostate cancer cell lines, University of Michigan (U-M) researchers have demonstrated the preliminary effectiveness of a new set of compounds that offer a potential advance in the treatment of metastatic castration-resistant prostate cancer — one that appears to avoid many of the usual mechanisms of treatment resistance.
Researcher looks through microscope to explore tissue regeneration
Tuesday, September 10, 2019 Interdisciplinary U-M Team Uses Mouse Models to Make Strides in Tissue Regeneration Research
Groundbreaking new research involving mouse models marries high-intensity focused ultrasound with genetically modified cells, which may spur bone and soft tissue regeneration.
Animal technician holds black mouse in clear enrichment tube
Wednesday, July 10, 2019 Researchers Look to Mice to Better Understand the Formation of Dangerous Blood Clots
Recent research from Michigan Medicine scientists may help solve the mystery of how to detect and deal with higher-than-usual blood clot risk in patients who have experienced unprovoked venous thromboembolism. The study, done in mice and published in the Journal of Clinical Investigation, explores the role of inflammation in the development of deep vein thrombosis.
Researcher looks at brain scans on a handheld tablet
Tuesday, June 25, 2019 Mouse Models Help Overcome Challenges to Finding Predictive Biomarkers in Rare Cancers
Using a new approach that combines data from human tumors grown in mice with data from The Cancer Genome Atlas, a team led by University of Michigan Rogel Cancer Center researchers has uncovered several previously unknown biomarkers for glioblastoma, the most common malignant brain tumor.
Monday, June 10, 2019 Why Do Women Get Autoimmune Diseases Far More Often Than Men? Transgenic Mouse Study Suggests a Root Cause and Target for New Treatments
“Many patients are frustrated that they’ve had to try multiple therapies and still nothing is working well,” Allison Billi, M.D., Ph.D., says. “To be able to tell them that we’re working on a mouse that has the same disease as them, and that we need their help, brings out their motivation and interest in research.”
Male patient receives care in the BMT Adult Clinic
Wednesday, May 29, 2019 New Research in Mice Could Lead to Better Treatment, Repair of Liver Damage
U-M researchers have discovered that the enzyme CPS1 can spur the body to prevent or repair acute liver injury in mice, which could be harnessed as a therapy or used as a biomarker to treat patients with liver damage.

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