Our Impact

Technician holds brown mouse
Monday, August 16, 2021 Mouse Study Suggests that Targeting Skin Protein May Limit Inflammation in Psoriasis Patients
Using a model that mimics psoriasis in mice, researchers found that changing the levels of interferon kappa, a protein made by skin cells, altered the severity of inflammation and production of cell signaling molecules, called cytokines, that induce inflammation characteristic of psoriasis.
Foreground (from left): Research Laboratory Technician Anne Marie Weitzel, PC3L Associate Director Brendan McCracken, MS, and PC3L Director Hakam Tiba, MD, MS. Background: Research Laboratory Technician Carmen Colmenero, BS.
Monday, August 2, 2021 New Preclinical Research Models Could Lead to Better Diagnosis, Treatment of Sepsis and ARDS
Novel large animal research models developed at the University of Michigan Center for Integrative Research in Critical Care fill a crucial gap in the translational study of life-threatening critical illness and injury.
This sample of clinical triple-negative breast cancer is stained for bone morphogenetic protein-11 (red); the Golgi marker GM130 (green); glycosylated proteins (white); and nuclei (blue), illustrating profound molecular heterogeneity.
Wednesday, July 28, 2021 Mouse Models Aid in the Search for New Approaches to Treat Triple-Negative Breast Cancer
Breast cancer stem cells from patients with different racial and ethnic backgrounds showed important differences in activation of immune response-related genes in mouse models. This work suggests that further exploration may help develop new approaches to treat triple-negative breast cancer, thus helping reduce survival disparities in women with African ancestry.
Pictured from left-to-right: L-R: Zhe Wu, Jiane Feng, Lauren Benson, Eric Westfall, Kristina Metz, Nathan Qi, M.D., Ph.D. Not pictured: Malcolm Low, M.D., Ph.D.
Monday, July 12, 2021 Small Lab Leans on Integrity to Become Nationally-Recognized Phenotyping Center
It was a lonely first day at work for Nathan Qi, M.D., Ph.D., on March 1, 2006, as the one and only researcher at the new Animal Phenotyping Core. Now, the 3,000-foot lab is among the top five metabolic phenotyping centers in the country. With a $6 million NIH grant fulfilled and more in progress, Qi’s team works to teach established investigators, postdoctoral fellows, and students at Michigan Medicine how their phenotyping animal research complements related human studies.
Illustration of histotripsy technology. Image courtesy of Medicine at Michigan Magazine
Wednesday, June 30, 2021 Ultrasound Technology Developed at U-M, Analyzed in Mouse Models Heads to Clinical Trials
The #HOPE4LIVER trial will evaluate the safety and efficacy of histotripsy against liver tumors at eight U.S. sites, including the University of Michigan.
Illustration of a T cell attacking a cancer cell. Roger Harris/Science Photo Library via Getty Images.
Wednesday, June 16, 2021 Researchers Discover First Immune Stimulating Long Noncoding RNA Involved in Body's Response to Cancer
The findings in human cells and animal models suggest potential approaches to improve immunotherapy treatment against cancer.
Getty Images: Woman reacting to allergies in outside air with Kleenex
Tuesday, June 1, 2021 Animal Model Helps Uncover Key Molecule that Drives Production of Cells Critical to Allergic Reactions
U-M researchers have discovered a protein that regulates the gene expression for influential immune cells, paving a path for novel targets to treat inflammatory and allergic diseases.
File photo: The Chinnaiyan Lab leveraged its work in prostate cancer to understand how a key protein functions in COVID-19. Credit: Leisa Thompson
Monday, March 1, 2021 Mouse Study Affirms the Role of Prostate Cancer Regulator in COVID-19
Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus.
Two black mice play in enclosure with enrichment items
Tuesday, February 16, 2021 Ginger Counters Certain Autoimmune Diseases in Mice
The main bioactive compound of ginger root lowers autoantibody production and helps halt disease progression in mice with antiphospholipid syndrome and lupus.
Doctor in patient room using stethoscope
Tuesday, December 22, 2020 Animal Models Helping Researchers Make Strides Against Childhood Brain Cancers
A roundup of several recent Michigan Medicine discoveries involving mouse models that are shedding new light on pediatric brain cancers and helping to improve treatment options.

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