Our Impact

A common mutation in a rare cancer subtype leads researchers to an already-approved drug that shows promise against uterine serous carcinoma.

Technique pioneered in rats at the University of Michigan could improve outcomes for cancer and neurological conditions.

Mouse model reveals gut inflammation makes it easier for bacterium to set up shop.

Treating peanut allergy with microneedles, a novel immunotherapy, could significantly improve desensitization by directly targeting the allergen to the skin, providing greater protection from severe allergic reactions for millions of people, a new study suggests.

Blocking the activity of an enzyme inside fat cells can decrease obesity and related health disorders in mice, according to new research led by the University of Michigan Life Sciences Institute.

An international team of scientists has identified how a protein in the brain uses information about the body's energy balance to regulate growth rate and the onset of puberty in children.

In cell and mouse models, metformin suppressed tumor growth in group A posterior fossa ependymomas.

A new study, first started in mice, reveals the mechanism behind cytokine storm during coronavirus infection.

Using a model that mimics psoriasis in mice, researchers found that changing the levels of interferon kappa, a protein made by skin cells, altered the severity of inflammation and production of cell signaling molecules, called cytokines, that induce inflammation characteristic of psoriasis.

Novel large animal research models developed at the University of Michigan Center for Integrative Research in Critical Care fill a crucial gap in the translational study of life-threatening critical illness and injury.