Our Impact

Caitlin O'Connor, Ph.D., is a research fellow in the Narla lab. Credit: Daryl Marshke
Friday, May 6, 2022 Mouse Model Helps Researchers Zero in on Therapeutic Target for Aggressive Uterine Cancer
A common mutation in a rare cancer subtype leads researchers to an already-approved drug that shows promise against uterine serous carcinoma.
Zhen Xu, Professor of Biomedical Engineering and Tejaswi Worlikar, Biomedical Engineering PhD student discuss the 700kHz, 260-element histotripsy ultrasound array transducer they use in Prof. Xu’s lab. Credit: Marcin Szczepanski, Michigan Engineering
Wednesday, April 20, 2022 Tumors Partially Destroyed with Sound Don’t Come Back
Technique pioneered in rats at the University of Michigan could improve outcomes for cancer and neurological conditions.
Computer illustration of Clostridioides difficile bacteria
Tuesday, March 29, 2022 Investigating the Relationship Between Inflammatory Bowel Disease and C. diff
Mouse model reveals gut inflammation makes it easier for bacterium to set up shop.
Researcher donning personal protective equipment holds small black mouse
Wednesday, March 23, 2022 Microneedle Approach to Address Peanut Allergy Shows Promise in Mice
Treating peanut allergy with microneedles, a novel immunotherapy, could significantly improve desensitization by directly targeting the allergen to the skin, providing greater protection from severe allergic reactions for millions of people, a new study suggests.
Two black mice play in clear tunnel with nesting material
Wednesday, February 9, 2022 Obesity in Mice Lowered by Increasing Effects of Key Weight-Regulating Hormone
Blocking the activity of an enzyme inside fat cells can decrease obesity and related health disorders in mice, according to new research led by the University of Michigan Life Sciences Institute.
Pink and blue illustration of human brain activity
Monday, November 15, 2021 Study in Mice Identifies Link Between Reproductive Status and Metabolism
An international team of scientists has identified how a protein in the brain uses information about the body's energy balance to regulate growth rate and the onset of puberty in children.
Getty Images. 3D Model of metformin molecular structure with prescription pill bottles.
Friday, October 29, 2021 Common Diabetes Drug Promising Against Rare Childhood Brain Tumor in Laboratory Studies
In cell and mouse models, metformin suppressed tumor growth in group A posterior fossa ependymomas.
Masked woman receives blood glucose check
Wednesday, September 29, 2021 Why Do People with Diabetes Develop Severe COVID-19?
A new study, first started in mice, reveals the mechanism behind cytokine storm during coronavirus infection.
Technician holds brown mouse
Monday, August 16, 2021 Mouse Study Suggests that Targeting Skin Protein May Limit Inflammation in Psoriasis Patients
Using a model that mimics psoriasis in mice, researchers found that changing the levels of interferon kappa, a protein made by skin cells, altered the severity of inflammation and production of cell signaling molecules, called cytokines, that induce inflammation characteristic of psoriasis.
Foreground (from left): Research Laboratory Technician Anne Marie Weitzel, PC3L Associate Director Brendan McCracken, MS, and PC3L Director Hakam Tiba, MD, MS. Background: Research Laboratory Technician Carmen Colmenero, BS.
Monday, August 2, 2021 New Preclinical Research Models Could Lead to Better Diagnosis, Treatment of Sepsis and ARDS
Novel large animal research models developed at the University of Michigan Center for Integrative Research in Critical Care fill a crucial gap in the translational study of life-threatening critical illness and injury.