Our Impact

Researcher donning green gloves holds small black mouse
Monday, July 30, 2018 Mice Help Researchers Uncover Intricate Cellular Process Critical to Small Intestine Development
More than 40 percent of our small intestine develops before we are even born. But problems with this process in utero can result in a rare but deadly condition known as congenital short bowel syndrome. A new Michigan Medicine study conducted with mice has helped researchers uncover the surprising sequence of cellular events responsible for proper development of the small intestine.
Lab personnel holds white rat
Monday, July 23, 2018 New Rat Study May Provide Important Clues for Outsmarting Obesity
Researchers have found that obesity-prone rats respond more strongly to food-related cues, including specific changes in cells of the same brain area linked to addiction. The model, researchers say, can be used to figure out the neural and psychological differences that drive overeating before obesity sets in — a huge step to improve obesity prevention.
Illustration depicts scarring from idiopathic pulmonary fibrosis
Monday, June 4, 2018 Mouse Model Aids in Discovery of New Treatment Options for Idiopathic Pulmonary Fibrosis
Successfully tested in mice, targeted drug and gene therapies might one day benefit patients with a deadly lung disease, new U-M research finds.
DNA HiSeq 2000 at the University of Michigan
Sunday, May 20, 2018 Common Thread Found in Mice, Humans Offers Clues for Treating Brain Dysfunction After Sepsis
U-M researchers use mouse models and 16S rRNA gene sequencing to explore the previously unstudied role of gut microbes, or microbiome, in the development of long-term cognitive impairments after sepsis infection.
Black and white mice play in mouse cage
Monday, April 30, 2018 New Platform for Delivering Cancer Treatment Shows Great Promise in Mouse Models
U-M researchers have designed a new delivery system – a drug hidden in a nanodisc – to increase the number of patients who can be treated successfully with cancer immunotherapy drugs. The novel platform for chemoimmunotherapy triggered anti-tumor immunity and eliminated colon cancer in 85 percent of treated mice.
Illustration of mouse looking at peanut
Sunday, April 15, 2018 U-M Researchers Have Developed A New Vaccine That Suppresses Peanut Allergies in Mice
After nearly two decades spent developing a vaccine agent, U-M researchers have translated this work to the development of a vaccine to treat food allergies. In their new study, the team demonstrates that this vaccine may successfully turn off peanut allergy in mice by altering the immune cell response to peanut exposure.
Dr. Robert Bartlett with a patient and family
Tuesday, April 10, 2018 Animal Model, ECMO Technology Used to Help Develop Innovative Artificial Placenta
Using an animal model, U-M researchers are making progress on an extraordinary new artificial womb technology that could one day revolutionize the care of premature infants.
Anteroposterior (AP) x-ray shows signs of non-encapsulated pulmonary cryptococcosis in a human patient infected with Cryptococcus sp. fungal organisms.
Thursday, March 15, 2018 Mouse Model Helps Researchers Examine Specific Mechanisms Underlying Cryptococcal Disease
The results obtained from this animal study may provide important guidance for the development and use of anti-inflammatory therapies to minimize central nervous system injury in patients with severe cryptococcal infections, a major source of illness in people with HIV and AIDS.
Veterinarian holds black mouse in laboratory
Thursday, February 22, 2018 Mouse Study Could Pave the Way for New Approaches to Treating Obesity
"Whenever you generate mice exhibiting human disease-like phenotypes,” notes study team lead Ling Qi, Ph.D., “you know you are working on something with fundamental importance."
Zebrafish swims in shuttle tank with enrichment items
Friday, February 9, 2018 Newly Identified RNA Protein in Zebrafish, Mice Could Serve as a Target for the Development of a New Cancer-Fighting Drug
Researchers at the University of Michigan Comprehensive Cancer Center have identified and characterized a new long noncoding RNA (lncRNA), called THOR, that is expressed in humans, mice, and zebrafish. It’s unusual for this type of RNA to be conserved throughout species like this. The team’s thinking was that if the RNA plays a role in other animals and species besides humans, it must be important.