Our Impact

Breast cancer stem cells from patients with different racial and ethnic backgrounds showed important differences in activation of immune response-related genes in mouse models. This work suggests that further exploration may help develop new approaches to treat triple-negative breast cancer, thus helping reduce survival disparities in women with African ancestry.

It was a lonely first day at work for Nathan Qi, M.D., Ph.D., on March 1, 2006, as the one and only researcher at the new Animal Phenotyping Core. Now, the 3,000-foot lab is among the top five metabolic phenotyping centers in the country. With a $6 million NIH grant fulfilled and more in progress, Qi’s team works to teach established investigators, postdoctoral fellows, and students at Michigan Medicine how their phenotyping animal research complements related human studies.

The #HOPE4LIVER trial will evaluate the safety and efficacy of histotripsy against liver tumors at eight U.S. sites, including the University of Michigan.

The findings in human cells and animal models suggest potential approaches to improve immunotherapy treatment against cancer.

U-M researchers have discovered a protein that regulates the gene expression for influential immune cells, paving a path for novel targets to treat inflammatory and allergic diseases.

Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus.

The main bioactive compound of ginger root lowers autoantibody production and helps halt disease progression in mice with antiphospholipid syndrome and lupus.

A roundup of several recent Michigan Medicine discoveries involving mouse models that are shedding new light on pediatric brain cancers and helping to improve treatment options.

Animal model observation may reveal new cause of hypertension.

A new University of Michigan study reveals that the virus triggers production of antibodies circulating through the blood, causing clots in people hospitalized with the disease.