ULAM Pathology Core
The Pathology Core, run by the Unit for Laboratory Animal Medicine (ULAM), is a recharge-based research pathology laboratory providing anatomic and clinical pathology services to the U-M research community, including diagnostic support for U-M’s veterinary care program.
Sample Submission Deadlines for the Thanksgiving Holiday
The ULAM Pathology Core will be closed beginning at 12:00 PM (noon) on Wednesday, November 27 – Friday, November 29, 2024, in observance of the U-M’s Thanksgiving holiday.
To allow staff sufficient time before the break to process samples to a stable stage, histology samples must be received by 4:00 PM on Friday, November 22. Hematology/chemistry/send-outs must be received by 12:00 PM on Tuesday, November 26.
Oversight is provided by board-certified, veterinary pathologists with extensive experience in research pathology. Technical staff have certification and/or experience in histology or animal health related fields. Only projects utilizing animal tissues or de-identified (research only) human tissues are supported. Quality assurance is maintained through the use of internal SOPs and participation in an externally administered quality assurance program.
The ULAM Pathology Core provides only pathology-based services. For technical assistance with live animal procedures, please see the ULAM Technical Services team.
ULAM Pathology Core Missions: Research & Diagnostic Support
- Research submissions: ULAM Pathology Core research support services are available on a recharge basis by direct submission to ULAM Pathology Core. Recharge rates are approved by the University and are based upon cost-recovery. Estimates and letters of support are available and pre-project consultation is encouraged. See Service Areas below for available services, rates, and submission instructions.
- Animal Diagnostic submissions: ULAM Pathology Core also provides diagnostic pathology services to the veterinary care program. These services are for the identification of unanticipated animal illnesses and are not recharged to the investigator. Results are provided to the researcher, but diagnostic pathology reports are not intended to provide controlled research data. Diagnostic pathology services are available by contacting the ULAM Veterinary Care Team.
- Our main laboratory is located on the ground floor of B36 in the North Campus Research Complex (NCRC) and our satellite facility is in the MSAB building on the Medical Campus. Samples may be dropped off/picked up by appointment at either location with daily sample courier service between the campuses.
ULAM Pathology Core Services
Expand each section below for service details and rates, or request services in MiCORES.
- Rodent and large animal necropsy or tissue collection by ULAM Pathology Core personnel
- Use of large or small animal necropsy room for necropsy by investigators
- Tissue trimming and cassetting for histology by ULAM Pathology Core personnel
- Necropsy RATES
- Paraffin processing/embedding
- Frozen and paraffin sectioning
- Hematoxylin and eosin staining and special histochemical stains
- Immunohistochemistry (IHC)
- Self-service frozen sectioning (animal tissues only)
- Histology/Immunohistochemistry RATES
- Clinical pathology: Animal hematology/clinical chemistry & diagnostic testing
- Complete blood counts (CBC) using Heska HT5 Element (Heska)
- Serum chemistry using Liasys analyzer (AMS Alliance)
- Cytology, including blood smears
- Other testing: Urinalysis, parasitology
- Biological indicator verification (sterility strip verification)
- Microbiology and other diagnostic services (through external laboratories)
- Clinical Pathology RATES
- Digital slide scanning using Leica Aperio AT2® scanner
- Publication-quality images
- Digital slide files suitable for image analysis and quantitative morphometry
- Digital slides scanning RATES
- Descriptive or quantitative histology interpretation by board-certified veterinary pathologists
- Interpretation of animal hematology and serum chemistry results
- Image analysis by board-certified veterinary pathologists
- Contact us at [email protected] for more information
ULAM Pathology Core Frequently Requested Information
Expand each section below for additional information.
ULAM Pathology Core Lab Submissions (Necropsy, Histology, Clinical Pathology, Slide Scanning, Pathology): 1-2-3
Submit a request in MiCORES for any of the following services:
- Necropsy, Histology, and Pathology Requests
- Digital Scanning Requests
- Clinical Pathology Lab Requests
- Outside Laboratory Requests (shipping samples to an outside lab)
In the request, note your sample drop-off date/time and location preferences. An appointment will be scheduled for you by the ULAM Pathology Core Team.
WAIT for a confirmed appointment, then bring your samples in a clean secondary container at the time of your appointment. Label your samples with the Service ID from your request (as found in your appointment confirmation email).
ULAM Pathology Core Sample Submission Guidelines
Samples may be dropped off at either location (below) by appointment only. Submit your request for services in MiCORES and note your sample drop-off date/time and location preference. An appointment will be scheduled for you by the ULAM Pathology Core Team.
Sample courier service is available daily between the two locations. Please email at least 24 hours in advance for hematology/chemistry requests.
Two weeks’ notice is requested for Research Necropsy Requests. Diagnostic necropsy requests (for spontaneous conditions unrelated to research) are made through the ULAM Veterinary Care Team.
Main: B36/G157A, NCRC
Monday – Friday
9:00 AM – 4:00 PM
2800 Plymouth Road
Ann Arbor, MI 48109
(734) 936-3395
Satellite: 3527 MSAB
Monday – Friday
9:00 AM – 3:00 PM
1150 W. Medical Center Drive
Ann Arbor, MI 48109
(734) 936-3803
ULAM Pathology Core – Necropsy Rates
DESCRIPTION
RATE
EFFECTIVE
Tissue Preparation
Trim/Cassette (Paraffin)
$ 13.50
08/01/2024
Embed in OCT (frozen tissue, per sample)
$ 18.00
08/01/2024
Decalcification (tissue in cassette)
$ 12.86
08/01/2024
Decalcification (larger tissue)
$ 19.17
08/01/2024
Necropsy
Fixed Animal Necropsy
$ 96.29
08/01/2024
Small Animal Necropsy
$ 88.38
08/01/2024
Medium Animal Necropsy
$ 176.93
08/01/2024
Large Animal Necropsy
$ 393.21
08/01/2024
Large Animal Biohazard Necropsy
$ 507.48
08/01/2024
Necropsy Technician Labor (REG)
$ 60.00
08/01/2024
Necropsy Technician Labor (OT)
$ 90.00
08/01/2024
Spatial biology, paraffin, unstained, per sample (regular slide)
$ 15.00
08/01/2024
Spatial biology, paraffin section & HE, per sample (regular slide)
$ 25.00
08/01/2024
Spatial biology, paraffin, unstained, per sample, specialty slide (any platform)
$ 35.00
08/01/2024
DNAse/RNAse-free, paraffin scrolls, per sample
$ 15.00
08/01/2024
Spatial biology, frozen, unstained, per sample (regular slide)
$ 25.00
08/01/2024
Spatial biology, frozen section & HE, per sample (regular slide)
$ 35.00
08/01/2024
Spatial biology, frozen, unstained, per sample, specialty slide (any platform)
$ 45.00
08/01/2024
Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.
ULAM Pathology Core – Histology Rates
DESCRIPTION
RATE
EFFECTIVE
Standard Histology Procedures
Frozen H&E Slide (section & stain) – simple^^
$ 19.48
08/01/2024
Frozen H&E Slide (section & stain) – complex++
$ 25.00
08/01/2024
Frozen Unstained Slide – simple (return unstained)
$ 17.46
08/01/2024
Frozen Unstained Slide – complex (return unstained)
$ 23.00
08/01/2024
Frozen Unstained Slide – simple (for CORE to stain, Specials or IHC)
$ 17.46
08/01/2024
Frozen Unstained Slide – complex (for CORE to stain, Specials or IHC)
$ 23.00
08/01/2024
H&E Stain Only, automated (slide provided by PI)
$ 6.09
08/01/2024
H&E Stain Only, manual
$ 8.00
08/01/2024
Histology Technician Extra Labor (REG)
$ 60.00
08/01/2024
Histology Technician Extra Labor (OT)
$ 90.00
08/01/2024
Cryostat (self-service)
$ 14.75
08/01/2024
Paraffin H&E slide, simple (section & stain)
$ 8.00
08/01/2024
Paraffin H&E slide, complex (section & stain)
$ 13.50
08/01/2024
Paraffin Processing & Embed, simple
$ 7.98
08/01/2024
Paraffin Processing & Embed, complex
$ 10.98
08/01/2024
Paraffin Embed Only, simple
$ 5.98
08/01/2024
Paraffin Embed Only, complex
$ 8.98
08/01/2024
Paraffin Unstained Slide, simple (return unstained)
$ 6.51
08/01/2024
Paraffin Unstained Slide, complex (return unstained)
$ 12.00
08/01/2024
Paraffin Unstained Slide, simple (for CORE to stain, Specials or IHC)
$ 6.51
08/01/2024
Paraffin Unstained Slide, complex (for CORE to stain, Specials or IHC)
$ 12.00
08/01/2024
^^Simple: visceral organs (kidney, liver, etc.), up to two sections per slide, skin, or GI (non-step, non-serial)
++Complex: step sections, serial sections (>2), >2 of any tissue per slide, bone sections, non-rodent brain sections, specialized tissue targets (cardiac valve leaflets, etc.)
Immunohistochemistry Stains
IHC aSMA
$ 53.76
08/01/2024
IHC CD45R-B220
$ 53.76
08/01/2024
IHC CD3
$ 53.76
08/01/2024
IHC CD4
$ 61.19
08/01/2024
IHC CD8a
$ 61.19
08/01/2024
IHC CD20
$ 53.76
08/01/2024
IHC CD31
$ 61.19
08/01/2024
IHC Cleaved Caspase-3
$ 53.76
08/01/2024
IHC F4/80
$ 53.76
08/01/2024
IHC GFP
$ 53.76
08/01/2024
IHC Ki67
$ 53.76
08/01/2024
IHC Ly-6G
$ 53.76
08/01/2024
IHC Lyve-1
$ 53.76
08/01/2024
IHC Mac2
$ 53.36
08/01/2024
IHC Von Willebrand Factor
$ 61.19
08/01/2024
IHC Negative Control
$ 49.27
08/01/2024
IHC Positive Control
$ 49.27
08/01/2024
IHC Stain, Paraffin, Other (antibody provided by PI)
$ 51.48
08/01/2024
IHC Stain, New Antibody Optimization Slide
$ 57.16
08/01/2024
IHC Stain, Frozen, Other (antibody provided by PI)
$ 54.70
08/01/2024
Special Histochemical Stains
Special Stain Gram
$ 61.97
08/01/2024
Special Stain Luxol Fast Blue (LFB)
$ 35.42
08/01/2024
Special Stain Masson Trichrome (MTC)
$ 28.15
08/01/2024
Special Stain Masson Trichrome Verhoeff (MTCV)
$ 35.42
08/01/2024
Special Stain Warthin-Starry
$ 61.97
08/01/2024
Special Stain Other
$ 61.97
08/01/2024
Special Stain Picrosirius Red (PSR)
$ 28.15
08/01/2024
Special Stain Prussian Blue
$ 53.12
08/01/2024
Special Stain Toluidine Blue
$ 35.42
08/01/2024
Special Stain Verhoeff Van Gieson (VVG)
$ 35.42
08/01/2024
Special Stain Alcian Blue (AB)
$ 35.42
08/01/2024
Special Stain Alcian Blue PAS (AB-PAS)
$ 53.12
08/01/2024
Special Stain Alizarin Red
$ 53.12
08/01/2024
Special Stain Congo Red
$ 53.12
08/01/2024
Special Stain Luxol Fast Blue PAS (LFB-PAS)
$ 53.12
08/01/2024
Special Stain Luxol Fast Blue Eosin (LFB-E)
$ 53.12
08/01/2024
Special Stain Oil Red O (ORO)
$ 61.97
08/01/2024
Special Stain Periodic Acid Schiff (PAS)
$ 35.42
08/01/2024
Special Stain Grocott Methanamine Silver (GMS)
$ 61.97
08/01/2024
Special Stain Gordon & Sweet’s Reticulin
$ 61.97
08/01/2024
Special Stain Jones Methenamine Silver (JMS)
$ 61.97
08/01/2024
Special Stain Russell-Movat Pentachrome
$ 53.12
08/01/2024
Special Stain Ziehl Neelson
$ 61.97
08/01/2024
Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.
ULAM Pathology Core – Animal Clinical Pathology Laboratory Testing Rates
DESCRIPTION
RATE
EFFECTIVE
1 Chemistry Only/ Animal
$ 25.42
08/01/2024
Custom Panel, 2 Chemistries/Animal
$ 41.48
08/01/2024
Custom Panel, 3 Chemistries/Animal
$ 52.20
08/01/2024
Custom Panel, 4 Chemistries/Animal
$ 61.08
08/01/2024
Custom Panel, 5 Chemistries/Animal
$ 69.12
08/01/2024
Add-on (to panel), One Chemistry
$ 7.26
08/01/2024
Animal Clinical Pathology Laboratory Technician Labor (REG)
$ 60.00
08/01/2024
Animal Clinical Pathology Laboratory Technician Labor (OT)
$ 90.00
08/01/2024
C. Difficile ELISA (MSU)
$ 81.94
08/01/2024
C. Perfringens ELISA (MSU)
$ 62.74
08/01/2024
Clostridia ELISA (MSU)
$ 106.52
08/01/2024
Fecal Culture (MSU)
$ 60.86
08/01/2024
General Culture (MSU)
$ 76.14
08/01/2024
PCR for SRV (VRL)
$ 161.65
08/01/2024
PCR for Essential Xenopus Panel (Idexx)
$ 108.05
08/01/2024
Urine Culture & Susceptibility
$ 68.39
08/01/2024
Anaerobic Culture (MSU)
$ 50.33
08/01/2024
Blood Culture & Susceptibility (MSU)
$ 112.50
08/01/2024
Blood Smear (prep only)
$ 13.77
08/01/2024
Complete Blood Count (CBC) w/ Auto Differential
$ 27.23
08/01/2024
Cytology Slide, Diff-Quick (prep only)
$ 13.77
08/01/2024
Direct Smear for Parasites
$ 31.41
08/01/2024
Ectoparasite Exam, Microscopic
$ 12.71
08/01/2024
Electrolytes
$ 24.56
08/01/2024
Fecal Culture & Susceptibility (MSU)
$ 100.06
08/01/2024
Fecal Flotation
$ 41.33
08/01/2024
Full Chemistry Panel
$ 71.49
08/01/2024
Fungal Culture (MSU)
$ 59.32
08/01/2024
General Culture & Susceptibility (MSU)
$ 88.04
08/01/2024
Hematocrit, Spun
$ 18.91
08/01/2024
Herpes B Cell Culture, Virology (GSU)
$ 279.79
08/01/2024
Herpes B Serology – Antibody (GSU)
$ 149.21
08/01/2024
Insulated Sample Transport Box
$ 28.98
08/01/2024
Laboratory Sendout Processing Fee
$ 27.16
08/01/2024
Liver Panel
$ 51.71
08/01/2024
Manual (WBC) Differential
$ 38.91
08/01/2024
McMasters Fecal Exam
$ 24.88
08/01/2024
Mini Chem Panel
$ 52.25
08/01/2024
Mini Liver Panel
$ 29.25
08/01/2024
Pig Full Chemistry Panel
$ 76.57
08/01/2024
PT/PTT
$ 72.39
08/01/2024
Renal Panel
$ 37.24
08/01/2024
Reticulocyte Count
$ 39.33
08/01/2024
Room Temp Sample Transport Box
$ 14.06
08/01/2024
Total Protein, Refractometer
$ 22.09
08/01/2024
Urinalysis, Complete
$ 46.12
08/01/2024
Urinalysis, Routine
$ 44.84
08/01/2024
Gram Stain Slide Prep/Interpretation
$ 12.27
08/01/2024
Verify Ampule (autoclave control)
$ 21.90
08/01/2024
Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.
The facilities are operated on a fee-for-service basis. Users are charged based on the amount of time technicians spend performing the services.
ULAM Pathology Core – Aperio® Digital Slide Scanning Rates
DESCRIPTION
RATE
EFFECTIVE
Digital slide scan, Technician Labor (REG)
$ 60.00
08/01/2024
Digital slide scan, Technician Labor (OT)
$ 90.00
08/01/2024
Digital slide scan, 20x, batch >50 slides, each
$ 9.64
08/01/2024
Digital slide scan, 20x, batch 20-50 slides, each
$ 11.27
08/01/2024
Digital slide scan, 20x, <20 slides, each
$ 13.73
08/01/2024
Digital slide scan, 40x, batch >50 slides, each
$ 10.60
08/01/2024
Digital slide scan, 40x, batch 20-50 slides, each
$ 12.59
08/01/2024
Digital slide scan, 40x, <20 slides, each
$ 14.48
08/01/2024
ULAM Pathology Core – Pathologist Rates
DESCRIPTION
RATE
EFFECTIVE
ULAM Pathology Core Pathologist Analysis Service
$ 285.00
08/01/2024
*Rates subject to change.
ULAM Pathology Core Authorship/Acknowledgment Policies
References and Resources
ULAM Pathology Core MiCORES Submission Guide (PDF download)
ULAM Pathology Core Digital Slide Scanning Sample Guidelines (PDF download)
ULAM Pathology Core Histology Sample Guidelines (PDF download)
ULAM Diagnostic Case Request Form
ULAM Employees Only. Requires special permissions and valid U-M login credentials.
Questions?
For questions, estimates, or consults about the ULAM Pathology Core’s services, contact [email protected].