Report Animal Concerns

Our Mission

The Animal Care & Use Program supports the University of Michigan community in its pursuit of impactful science to benefit both human and animal health by fostering a culture of excellence and compassion, responsible research conduct, and a shared commitment to upholding the highest animal welfare standards in all aspects of research and instruction.

A Message from Our Leadership

For decades, laboratory animals have been essential to almost every major advancement in human and animal medicine. The University of Michigan (U-M) community is committed to the highest standards of excellent and humane care in the use of these animals in our research and instruction, and we believe that this commitment is central to the rigor and impact of our work.

Our approach goes beyond strict adherence to all required guidelines. In addition, we embrace the principles known as “the three Rs”: reducing the number of animals used to the minimum required for the study, replacing animals with less sentient or non-animal models whenever possible, and refining all practices to provide the best animal welfare possible.

Our Program comprises three units that support the entire U-M community and ensure our collective commitment to the welfare of all animals under our care:

Through projects and training activities that span a wide variety of fields, including medicine, dentistry, natural resources and the environment, engineering, public health, and kinesiology, scientific and medical knowledge developed through animal research has saved countless lives and improved health outcomes for both humans and animals.

Some examples of life-changing research projects and teaching programs at the University of Michigan are highlighted in the stories below. 

Regards,
 
William King, DVM, PhD, DACLAM
Associate Vice President for Research – Animal Care and Use Program
Attending Veterinarian
Executive Director, Unit for Laboratory Animal Medicine
Clinical Professor of Laboratory Animal Medicine

William Greer, BS, CPIA, LAT, CM
Assistant Vice President for Research – Animal Program Compliance Oversight
Director, Animal Care & Use Office

Daniel D. Myers, DVM, MPH, DACLAM
Professor of Surgery
Chair, Institutional Animal Care & Use Committee

Our Impact

Adult holding sick child's hand in hospital bed

Researchers Discover New Protein Target for Childhood Medulloblastomas

Higher levels of dihydrolipoyl transacetylase make Group-3 medulloblastomas vulnerable to copper-mediated death. Medulloblastomas are one of the most common childhood brain cancers. Particularly, Group-3 medulloblastomas are aggressive and incurable, contributing to childhood cancer deaths. Led by University of Michigan researchers, a study in Cancer Cell identified a new target for Group-3 medulloblastomas. The results help identify new …
Microscopic rendering of a colon cancer cell

Researchers Identify Role of Key Genes in Colon Cancer Development

Loss of the SOX9 gene results in greater tumor invasion and poor outcomes in mice. Colorectal cancer is the second leading cause of cancer-related death globally. Although some of the molecular changes associated with colorectal cancer are known, how they contribute to cancer development is not yet well defined. In a study published in the Journal …
Technician holds large white rat

Drug Combination Reduces Breast Cancer Risk and Improves Metabolic Health in Rats

Bazedoxifene and conjugated estrogens reversed obesity-associated changes, supporting their use in patients. Approximately 25% of women in the United States between the ages 45 and 60 are at high risk for breast cancer and should consider preventative medication, such as the commonly prescribed drug tamoxifen. Unfortunately, tamoxifen can cause side effects, including an increased risk …

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