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Germ-Free Mouse Facility

Established in 2004, the Germ-Free Mouse Facility, part of the Unit for Laboratory Animal Medicine (ULAM), provides services to the entire University of Michigan community and can also ship germ-free mice to locations worldwide. 

Primary and collaborative research projects include studies investigating inflammatory bowel disease and cancer, host microbiome interactions, infectious disease pathogenesis, and mammalian and bacterial metabolism, among others. The staff also performs research and training in gnotobiotic technology and methods.

A complete list of recent publications that include U-M’s Germ-Free Mouse Facility can be found on PubMed.

Users must have an approved animal use protocol from the Institutional Animal Care & Use Committee (IACUC) prior to utilizing Germ-Free Mouse Facility services and facilities.

About the Germ-Free Mouse Facility

Mice can be used in our facility or shipped to other facilities in germ-free shipping containers.

Available strains include:

  • C57BL/6
  • BALB/c
  • Swiss-Webster (outbred)
  • IL-10 knockout (B6.129P2-Il10tm1Cgn/J)
  • Others may be available upon request

Several varieties of germ-free and barrier housing are available:

Sterile:

Trexler-type soft-sided isolators can be used for breeding colonies and long-term germ-free or gnotobiotic housing

Barrier:

  • Microisolator cages can be kept sterile in biosafety cabinets for short-term experiments
  • Individual Isocages® (Tecniplast) can maintain germ-free or gnotobiotic conditions for long-term experiments
Germ-free technicians at Biosafety Cabinet
Biosafety Cabinets
Germ-Free breeding isolators
Breeding Isolators
Germ-Free isolator room
Isolator Room
Germ-Free double isolator
Double Isolator
  • Inoculation (oral and parenteral)
  • Sample collections, including:
    • Blood
    • Tissue
    • Feces
    • Body weights
    • Necropsy and tissue collection
  • Technical consultation
  • Other services may be available on request
Researcher in germ-free mouse facility conducting health check
Husbandry
  • Re-derivation of new germ-free strains
  • Consultation:
    • Experimental design
    • Pathology services
    • Histologic interpretation

Contract services may also be available.

Please contact ulam-germfree@umich.edu or call (734) 615-9420 for specific inquiries

Germ-Free isocage housing rack
Isocage Housing Rack

Facilities and associated services are offered on a fee-for-service basis. Users are charged for all supplies, technical assistance, and equipment used. Estimates are available upon request.

Germ-Free Mouse Facility Rates

DESCRIPTION

RATE

EFFECTIVE

Animal Procurement Rates

C57Bl/6 Germ-Free Mice < 8 weeks (per animal)

$ 85.45

07/01/2023

C57Bl/6 Germ-Free Mice > 8 weeks (per animal)

$ 115.81

07/01/2023

Swiss-Webster Germ-Free Mice < 8 weeks (per animal)

$ 73.78

07/01/2023

Swiss-Webster Germ-Free Mice > 8 weeks (per animal)

$ 81.21

07/01/2023

IL-10KO Germ-Free Mice < 8 weeks (per animal)

$ 85.45

07/01/2023

IL-10KO Germ-Free Mice > 8 weeks (per animal)

$ 115.81

07/01/2023

Rag1/KO Germ-Free Mice < 8 weeks (per animal)

$ 85.45

07/01/2023

Rag1/KO Germ-Free Mice > 8 weeks (per animal)

$ 115.81

07/01/2023

Germ-Free Rates

5-pack fecal kit

$ 22.47

07/01/2023

10-pack fecal kit

$ 24.50

07/01/2023

5-pack serum submandibular collection kit

$ 23.98

07/01/2023

10-pack serum submandibular collection kit

Discontinued

07/01/2023

5-pack whole blood submandibular collection kit

$ 25.00

07/01/2023

10-pack whole blood submandibular collection kit

$ 30.87

07/01/2023

Injection kit

$ 21.68

07/01/2023

Germ-Free per-diem (per cage/day)

$ 5.59

07/01/2023

Germ-Free shipper

Discontinued

07/01/2023

Gas sterilization – small

$ 26.97

07/01/2023

Gas sterilization – medium

$ 23.26

07/01/2023

Gas sterilization – large

$ 31.87

07/01/2023

Sterile mouse box transport kit

$ 25.04

07/01/2023

Oral gavage w/ feeding needle kit

$ 29.29

07/01/2023

Port entry/exit

$ 27.62

07/01/2023

*Rates subject to change.

Request Germ-Free Mice or Services

Download and complete the Germ-Free Request Form (available via PDF).

Download the pdf form

Mouse Metabolism Project?

Consider joining the Mouse Metabolic Phenotyping Consortium for special services.

learn more

References and Resources

To help us provide continued services, please remember to acknowledge the work of our core in your publications and presentations.
We adhere to the Association of Biomolecular Resource Facilities (ABRF) policies on Authorship and Acknowledgment.

review the abrf authorship guidelines

Questions?

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