Our Impact

Zebrafish facility at the University of Michigan
Friday, August 4, 2017 Retinal Repair Through a Fish-Eye Lens
Some animals are able to regrow tissues lost to injury or disease. Zebrafish do this in their retinas, which are remarkably similar to our own. So do humans also have these tools to repair a diseased retina? If so, what are they?
Black laboratory mouse
Friday, August 4, 2017 Study Done in Mice Could Offer Key to Stopping Clostridium Difficile
Researchers from the U-M Medical School and the FDA have published a new study that shows the key role of excess gut calcium in awakening C. diff spores; a discovery that could ultimately lead to better patient treatment.
Researcher holding brown mouse
Wednesday, April 26, 2017 New Mouse Model Aims to Find Novel Therapies to Prevent Chronic Lung Transplant Rejection
A team of U-M researchers has developed a novel mouse lung transplant model of chronic rejection to test if two new therapeutic treatments would decrease the scarring process in lung transplant patients.
Researcher examines white germ-free mouse
Wednesday, April 26, 2017 New Mice Study Shows Gut Bacteria May Protect Newborns Against Infections
Why do so many babies fall victim to infections that invade the gut but others don't? Research in germ-free mice yields important clues.
Researcher holding black mouse
Tuesday, February 28, 2017 Germ-Free Mice Study Shows Importance of High-Fiber Diet in Protecting Against Infection
Using U-M's germ-free mouse facility and advanced genetic techniques, an international team of researchers studied the impact of diets with different fiber content -- and those with no fiber. The findings show the importance of eating natural fiber to protect the digestive tract's vital mucus barrier.
Researcher donning personal protective equipment holds small black mouse
Sunday, February 5, 2017 New Mouse Model Leads to a Surprising Discovery that Sheds Light on Metaplastic Breast Cancer
For more than a decade, Celina Kleer, M.D., Harold A. Oberman Collegiate Professor of Pathology and director of the Breast Pathology Program at the U-M Cancer Center, has been studying how a poorly understood protein called CCN6 affects breast cancer. To learn more about its role in breast cancer development, Kleer's lab designed a special mouse model that deleted CCN6 from the mammary gland in mice, which allowed the team to study effects specific to the loss of the protein. The results, recently published in Oncogene, have revealed a key genetic driver for a rare form of metaplastic breast cancer.
Rats being studied in laboratory
Monday, December 12, 2016 U-M Researchers Share Rat Model with Scholars Worldwide
It's a pretty obvious connection - those who exercise more often are less susceptible to disease. But how exactly does a man’s aerobic capacity affect his chances of suffering a spontaneous heart attack? And how does a woman’s running ability impact her brain function? U-M researchers have developed a unique rat model that provides scientists worldwide with a significant resource to study how exercise endurance capacity correlates with disease risks.
Illustration showing how DNA markers influence addiction
Monday, December 12, 2016 Genetic Markers That Influence Addiction Discovered in Rat Study
Who gets hooked on drugs and who stays clean? New research, conducted in rats, identifies genetic markers that influence addiction.
Image of Mexican female fruit fly
Monday, December 12, 2016 Study in Fruit Flies Reveals Link Between Food and Life Span
Serotonin may motivate fruit flies to search for protein-rich foods. This, in turn, may reveal important clues to appetite and aging in humans.
Images of an MRI brain scan
Monday, December 12, 2016 Novel Mouse Model Offers Hope for Fighting Children's Brain Tumors
Children with brain tumors have had limited treatment options in the past compared with adults. A novel research model, developed in mice at U-M, will make it easier and faster to test new treatments.

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