Our Mission

The Animal Care & Use Program supports the University of Michigan community in its pursuit of impactful science to benefit both human and animal health by fostering a culture of excellence and compassion, responsible research conduct, and a shared commitment to upholding the highest animal welfare standards in all aspects of research and instruction.

A Message from Our Leadership

For decades, laboratory animals have been essential to almost every major advancement in human and animal medicine. The University of Michigan (U-M) community is committed to the highest standards of excellent and humane care in the use of these animals in our research and instruction, and we believe that this commitment is central to the rigor and impact of our work.

Our approach goes beyond strict adherence to all required guidelines. In addition, we embrace the principles known as “the three Rs”: reducing the number of animals used to the minimum required for the study, replacing animals with less sentient or non-animal models whenever possible, and refining all practices to provide the best animal welfare possible.

Our Program comprises three units that support the entire U-M community and ensure our collective commitment to the welfare of all animals under our care:

Through projects and training activities that span a wide variety of fields, including medicine, dentistry, natural resources and the environment, engineering, public health, and kinesiology, scientific and medical knowledge developed through animal research has saved countless lives and improved health outcomes for both humans and animals.

Some examples of life-changing research projects and teaching programs at the University of Michigan are highlighted in the stories below. 

Regards,
 
William King, DVM, PhD, DACLAM
Associate Vice President for Research – Animal Care and Use Program
Attending Veterinarian
Executive Director, Unit for Laboratory Animal Medicine
Clinical Professor of Laboratory Animal Medicine

William Greer, BS, CPIA, LAT, CM
Assistant Vice President for Research – Animal Program Compliance Oversight
Director, Animal Care & Use Office

Daniel D. Myers, DVM, MPH, DACLAM
Professor of Surgery
Chair, Institutional Animal Care & Use Committee

Our Impact

pink and blue mixed in close up microscopic view of tendon cells

Why Tendons Heal So Poorly and How Researchers Hope to Fix Them

Tiny “microtendons” help researchers study how tendon disease develops. About 30% of adults over age 60 have a rotator cuff tear, making it one of the most common tendon injuries in older adults. But unlike broken bones, tendons rarely heal completely. Add Achilles tendinopathy, tennis elbow, and other tendon injuries, and millions of Americans will …
Illustration of microbes inside gut

New Oral Nanomedicine Boosts Effectiveness of Cancer Immunotherapies

Microbial metabolite 3,4-dihydroxybenzoic acid, derived from dietary fiber, improves acid influences anti-tumor immunity in mice. Immune checkpoint blockade is a form of cancer treatment that works by releasing the natural brakes in the immune system, allowing T cells to find and destroy cancer cells. Although they have transformed cancer immunotherapy, patients usually have low response …
purple yellow red cells up close

Study Explains How Colorectal Cancer Cells Maintain High Iron Levels

Researchers identify metabolic process that could be a target for drug development. Researchers from the University of Michigan Health Rogel Cancer Center have discovered a key metabolic pathway that allows colorectal cancer cells to accumulate large quantities of iron. Blocking that pathway reduced iron levels and caused the cancer cells to die. Scientists know that …

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