In-Vivo Animal Core

Researchers load digital slides into scanner in In-Vivo Animal Core facility

The In-Vivo Animal Core (IVAC) is a core laboratory run by the Unit for Laboratory Animal Medicine (ULAM). Our mission is to provide histology, hematology/clinical chemistry, and pathology services in support of non-clinical research and the veterinary care program at the University of Michigan.

Our faculty and staff have years of experience encompassing academic biomedical research, pharmaceutical and environmental toxicology, and diagnostic veterinary pathology.

Our main laboratory is located on the ground floor of B36 in the North Campus Research Complex (NCRC) and our satellite facility is in the ARF building on the Medical Campus. Samples may be dropped off/picked up by appointment at either location with daily sample courier service between the campuses.

IVAC missions: Research and diagnostic support

  • Research submissions: IVAC research support services are available on a recharge basis by direct submission to IVAC. Recharge rates are approved by the University and are based upon cost-recovery. Estimates and letters of support are available and pre-project consultation is encouraged. See Service Areas below for available services, rates, and submission instructions.
  • Animal Diagnostic submissions: IVAC also provides diagnostic pathology services to the veterinary care program. These services are for the identification of unanticipated animal illnesses and are not recharged to the investigator. Results are provided to the researcher, but diagnostic pathology reports are not intended to provide controlled research data. Diagnostic pathology services are available by contacting the ULAM Veterinary Care Team.

IVAC Services & Rates

  • Rodent and large animal necropsy or tissue collection by IVAC personnel
  • Use of large or small animal necropsy room for necropsy by investigators
  • Tissue trimming and cassetting for histology by IVAC personnel
  • Necropsy RATES
  • Paraffin processing/embedding
  • Frozen and paraffin sectioning
  • Hematoxylin and eosin staining and special histochemical stains
  • Immunohistochemistry (IHC)
  • Self-service frozen sectioning (animal tissues only)
  • Histology/Immunohistochemistry RATES
  • Clinical pathology: Animal hematology/clinical chemistry & diagnostic testing
  • Complete blood counts (CBC) using Heska HT5 Element (Heska)
  • Serum chemistry using Liasys analyzer (AMS Alliance)
  • Cytology, including blood smears
  • Other testing: Urinalysis, parasitology
  • Biological indicator verification (sterility strip verification)
  • Microbiology and other diagnostic services (through external laboratories)
  • Clinical Pathology RATES
  • Digital slide scanning using Leica Aperio AT2® scanner
  • Publication-quality images
  • Digital slide files suitable for image analysis and quantitative morphometry
  • Digital slides scanning RATES
  • Blood/tissue collection
  • Animal monitoring (tumor size, clinical scoring)
  • Compound administration (gavage, injection, topical)
  • Ear tagging or other animal ID
  • Technical Services RATES
IVAC Lab Submissions (Necropsy, Histology, Clinical Pathology, Slide Scanning, Pathology): 1-2-3
  1. Download and complete a sample submission form. Please use separate forms for separate projects or service areas:
  2. Request an appointment to drop off your samples: Sample Drop-off Appointment Request
  3. WAIT for a confirmed appointment, then bring your submission form AND your samples in a clean secondary container at the time of your appointment.

 

IVAC Technical Service Requests
Fill out a Technical Services Request. Note: two weeks’ notice is typically needed. Contact ULAM-techservices@umich.edu with questions.

Samples may be dropped off at either location (below) by appointment only. Sample courier service is available daily between the two locations. Please email at least 24 hours in advance for hematology/chemistry requests.

Two weeks’ notice is requested for Research Necropsy or Technical Service Requests. Diagnostic necropsy requests (for spontaneous conditions unrelated to research) are made through the ULAM Veterinary Care Team.

     

MAIN: B36/G157A, NCRC
Monday – Friday, 9:00 AM – 4:00 PM

2800 Plymouth Road
Ann Arbor, MI 48109
(734) 936-3395
ulam-ivac@umich.edu

 

SATELLITE: 3527 ARF
Monday – Friday, 9:00 AM – 3:00 PM

1150 W. Medical Center Drive
Ann Arbor, MI 48109
(734) 936-3803
ulam-ivac@umich.edu

IVAC Necropsy Rates*

DESCRIPTION RATE EFFECTIVE
Tissue Preparation
Trim/Cassette (Paraffin or OCT) $  12.00 12/01/2020
Decalcification $  10.40 12/01/2020
 
Necropsy
Fixed Animal Necropsy $  78.00 12/01/2020
Small Animal Necropsy $  75.00 12/01/2020
Medium Animal Necropsy $  150.00 12/01/2020
Large Animal Necropsy $  320.00 12/01/2020
Large Animal Biohazard Necropsy $  422.50 12/01/2020
IVAC Necropsy Technician Labor/Hour Regular $  60.00 12/01/2020
IVAC Necropsy Technician Labor/Hour Overtime $  90.00 12/01/2020

 

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

IVAC Histology Rates*

DESCRIPTION RATE EFFECTIVE
Standard Histology Procedures
Paraffin H&E Slide (section & stain) $  7.65 12/01/2020
Paraffin Processing & Embedding $  4.59 12/01/2020
Paraffin Unstained Slides $  5.10 12/01/2020
H&E Stain (slide provided by PI) $  4.08 12/01/2020
Frozen H&E Slide (section & stain) $  11.22 12/01/2020
Frozen Unstained Slide $  10.20 12/01/2020
IVAC Histology Technician Labor/Hour Regular $  60.00 12/01/2020
IVAC Histology Technician Labor/Hour Overtime $  90.00 12/01/2020
Cryostat (self-service)/Hour $  10.00 12/01/2020
 
Immunohistochemistry Stains
IHC aSMA $  33.66 12/01/2020
IHC CD45R-B220 $  33.66 12/01/2020
IHC CD3 $  33.66 12/01/2020
IHC CD4 $  38.76 12/01/2020
IHC CD8a $  38.76 12/01/2020
IHC CD20 $  33.66 12/01/2020
IHC CD31 $  38.76 12/01/2020
IHC Cleaved Caspase-3 $  33.66 12/01/2020
IHC F4/80 $  33.66 12/01/2020
IHC GFP $  33.66 12/01/2020
IHC Ki67 $  33.66 12/01/2020
IHC Ly-6G $  33.66 12/01/2020
IHC Lyve-1 $  33.66 12/01/2020
IHC Mac2 $  33.66 12/01/2020
IHC Von Willebrand Factor $  38.76 12/01/2020
IHC Negative Control $  35.70 12/01/2020
IHC Stain (non-IVAC antibody, provided by PI) $  35.70 12/01/2020
IHC Stain – Titration Slide $  41.82 12/01/2020
IHC Stain – Frozen or IF Slide $  40.80 12/01/2020
 
Special Histochemical Stains
Special Stain Gram $  35.70 12/01/2020
Special Stain Luxol Fast Blue (LFB) $  20.40 12/01/2020
Special Stain Masson Trichrome (MTC) $  20.40 12/01/2020
Special Stain Other $  30.60 12/01/2020
Special Stain Picrosirius Red (PSR) $  20.40 12/01/2020
Special Stain Prussian Blue $  20.40 12/01/2020
Special Stain Toluidine Blue $  20.40 12/01/2020
Special Stain Verhoeff Van Gieson (VVG) $  35.70 12/01/2020
Special Stain Alcian Blue (AB) $  20.40 12/01/2020
Special Stain Alcian Blue PAS (AB-PAS) $  35.70 12/01/2020
Special Stain Alizarin Red $  30.60 12/01/2020
Special Stain Congo Red $  26.52 12/01/2020
Special Stain Luxol Fast Blue PAS (LFB-PAS) $  35.70 12/01/2020
Special Stain Oil Red O (ORO) $  30.60 12/01/2020
Special Stain Periodic Acid Schiff (PAS) $  20.40 12/01/2020
Special Stain Ziehl Neelson $  35.70 12/01/2020

 

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

IVAC Clinical Pathology: Hematology, Chemistry, Diagnostic Rates*

DESCRIPTION RATE EFFECTIVE
Serum Chemistry
1 Chemistry/Animal $  18.00 12/01/2020
2 Chemistries/Animal $  29.25 12/01/2020
3 Chemistries/Animal $  37.12 12/01/2020
4 Chemistries/Animal $  43.28 12/01/2020
5 Chemistries/Animal $  49.09 12/01/2020
Additional Chemistry Test $  5.15 12/01/2020
Full Chemistry Panel $  50.83 12/01/2020
Electrolytes $  17.42 12/01/2020
Mini Chem Panel $  37.15 12/01/2020
Mini Liver Panel $  20.80 12/01/2020
Pig Full Chemistry Panel $  54.43 12/01/2020
Liver Panel $  36.70 12/01/2020
Renal Panel $  26.47 12/01/2020
 
Hematology
Complete Blood Count (CBC) w/ Auto Differential $  19.36 12/01/2020
Blood Smear (prep only) $  9.78 12/01/2020
Manual (WBC) Differential $  27.65 12/01/2020
Reticulocyte Count $  27.96 12/01/2020
Hematocrit, Spun $  13.45 12/01/2020
PT/PTT $  51.49 12/01/2020
 
Other Clinical Pathology
TP, Refractometer $  15.70 12/01/2020
Urinalysis, Complete $  32.80 12/01/2020
Urinalysis, Routine $  31.88 12/01/2020
Fecal Flotation $  29.33 12/01/2020
ADL Technician Labor/Hour Regular $  60.00 12/01/2020
ADL Technician Labor/Hour Overtime $  90.00 12/01/2020
Laboratory Sendout Processing Fee $  19.31 12/01/2020
Microbial Culture please inquire
Animal Pathogen PCR (panels or single) please inquire

 

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

The facilities are operated on a fee-for-service basis. Users are charged based on the amount of time technicians spend performing the services.

IVAC Aperio® Digital Slide Scanning Rates* 

DESCRIPTION RATE EFFECTIVE
IVAC Aperio® Technician Labor/Hour Regular $  60.00 12/01/2020
IVAC Aperio® Technician Labor/Hour Overtime $  90.00 12/01/2020
Semi-automated, batch > 50 slides, each $  6.00 12/01/2020
Semi-automated, batch 20-50 slides, each $  8.00 12/01/2020
Semi-automated, each $  10.00 12/01/2020

IVAC Technical Services Rates*

DESCRIPTION RATE EFFECTIVE
IVAC Technical Services Technician Labor/Hour Regular $  60.00 12/01/2020
IVAC Technical Services Technician Labor/Hour Overtime $  90.00 12/01/2020

 

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

IVAC Pathologist Rates*

DESCRIPTION RATE EFFECTIVE
IVAC Pathologist Hourly Rate $  230.21 12/01/2020

 

*Rates subject to change.

Frequently Asked Questions & Resources

Our blood sample collection guidelines can be downloaded here.

Our available chemistry panels are listed here.

Our blood sample collection guidelines can be downloaded here.

Please fill out our Sample Drop-off Appointment Request to request a day/time for drop-off.

Our board-certified veterinary pathologists are available for assistance with results interpretation. Email ULAM-IVAC@umich.edu and request pathologist interpretation.

Please inquire at ULAM-IVAC@umich.edu

IVAC Authorship/Acknowledgment Policies

To help us provide continued services, please remember to acknowledge the work of our core in your publications and presentations. We adhere to the Association of Biomolecular Resource Facilities policies on Authorship and Acknowledgment

Questions?