In-Vivo Animal Core

Researchers load digital slides into scanner in In-Vivo Animal Core facility

The In-Vivo Animal Core (IVAC) is a core laboratory run by the Unit for Laboratory Animal Medicine (ULAM). Our mission is to provide histology, hematology/clinical chemistry, and pathology services in support of non-clinical research and the veterinary care program at the University of Michigan.

Our faculty and staff have years of experience encompassing academic biomedical research, pharmaceutical and environmental toxicology, and diagnostic veterinary pathology.

Our main laboratory is located on the ground floor of B36 in the North Campus Research Complex (NCRC) and our satellite facility is in the ARF building on the Medical Campus. Samples may be dropped off/picked up by appointment at either location with daily sample courier service between the campuses.

IVAC missions: Research and diagnostic support

  • Research submissions: IVAC research support services are available on a recharge basis by direct submission to IVAC. Recharge rates are approved by the University and are based upon cost-recovery. Estimates and letters of support are available and pre-project consultation is encouraged. See Service Areas below for available services, rates, and submission instructions.
  • Animal Diagnostic submissions: IVAC also provides diagnostic pathology services to the veterinary care program. These services are for the identification of unanticipated animal illnesses and are not recharged to the investigator. Results are provided to the researcher, but diagnostic pathology reports are not intended to provide controlled research data. Diagnostic pathology services are available by contacting the ULAM Veterinary Care Team.

IVAC Services & Rates

  • Rodent and large animal necropsy or tissue collection by IVAC personnel
  • Use of large or small animal necropsy room for necropsy by investigators
  • Tissue trimming and cassetting for histology by IVAC personnel
  • Necropsy RATES
  • Paraffin processing/embedding
  • Frozen and paraffin sectioning
  • Hematoxylin and eosin staining and special histochemical stains
  • Immunohistochemistry (IHC)
  • Self-service frozen sectioning (animal tissues only)
  • Histology/Immunohistochemistry RATES
  • Clinical pathology: Animal hematology/clinical chemistry & diagnostic testing
  • Complete blood counts (CBC) using Heska HT5 Element (Heska)
  • Serum chemistry using Liasys analyzer (AMS Alliance)
  • Cytology, including blood smears
  • Other testing: Urinalysis, parasitology
  • Biological indicator verification (sterility strip verification)
  • Microbiology and other diagnostic services (through external laboratories)
  • Clinical Pathology RATES
  • Digital slide scanning using Leica Aperio AT2® scanner
  • Publication-quality images
  • Digital slide files suitable for image analysis and quantitative morphometry
  • Digital slides scanning RATES
  • Blood/tissue collection
  • Animal monitoring (tumor size, clinical scoring)
  • Compound administration (gavage, injection, topical)
  • Ear tagging or other animal ID
  • Technical Services RATES
IVAC Lab Submissions (Necropsy, Histology, Clinical Pathology, Slide Scanning, Pathology): 1-2-3
  1. Download and complete a sample submission form. Please use separate forms for separate projects or service areas:
  2. Request an appointment to drop off your samples: Sample Drop-off Appointment Request
  3. WAIT for a confirmed appointment, then bring your submission form AND your samples in a clean secondary container at the time of your appointment.

 

IVAC Technical Service Requests
Fill out a Technical Services Request. Note: two weeks’ notice is typically needed. Contact ULAM-techservices@umich.edu with questions.

Samples may be dropped off at either location (below) by appointment only. Sample courier service is available daily between the two locations. Please email at least 24 hours in advance for hematology/chemistry requests.

Two weeks’ notice is requested for Research Necropsy or Technical Service Requests. Diagnostic necropsy requests (for spontaneous conditions unrelated to research) are made through the ULAM Veterinary Care Team.

     

MAIN: B36/G157A, NCRC
Monday – Friday, 9:00 AM – 4:00 PM

2800 Plymouth Road
Ann Arbor, MI 48109
(734) 936-3395
ulam-ivac@umich.edu

 

SATELLITE: 3527 ARF
Monday – Friday, 9:00 AM – 3:00 PM

1150 W. Medical Center Drive
Ann Arbor, MI 48109
(734) 936-3803
ulam-ivac@umich.edu

IVAC Necropsy Rates*

DESCRIPTION RATE EFFECTIVE
Tissue Preparation
Trim/Cassette (Paraffin or OCT) $  12.60 07/01/2021
Decalcification (tissue in cassette) $  10.92 07/01/2021
Decalcification (larger tissue) $  15.00 07/01/2021
 
Necropsy
Fixed Animal Necropsy $  81.90 07/01/2021
Small Animal Necropsy $  78.75 07/01/2021
Medium Animal Necropsy $  157.50 07/01/2021
Large Animal Necropsy $  336.00 07/01/2021
Large Animal Biohazard Necropsy $  443.63 07/01/2021
Necropsy Technician Labor/Hour Regular $  60.00 07/01/2021
Necropsy Technician Labor/Hour Overtime $  90.00 07/01/2021

 

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

IVAC Histology Rates*

DESCRIPTION RATE EFFECTIVE
Standard Histology Procedures
Paraffin H&E Slide (section & stain) $  6.12 07/01/2021
Paraffin Processing & Embedding $  3.67 07/01/2021
Paraffin Unstained Slides (returned unstained) $  4.08 07/01/2021
Paraffin Unstained Slides (for IVAC to stain, Specials or IHC) $  4.08 07/01/2021
H&E Stain only (slide provided by PI) $  3.26 07/01/2021
Frozen H&E Slide (section & stain) $  8.97 07/01/2021
Frozen Unstained Slide (returned unstained) $  8.16 07/01/2021
Frozen Unstained Slide (for IVAC to stain, Specials or IHC) $  8.16 07/01/2021
Histology Technician Labor/Hour Regular $  60.00 07/01/2021
Histology Technician Labor/Hour Overtime $  90.00 07/01/2021
Cryostat (self-service)/Hour $  10.00 07/01/2021
 
Immunohistochemistry Stains
IHC aSMA $  26.92 07/01/2021
IHC CD45R-B220 $  26.92 07/01/2021
IHC CD3 $  26.92 07/01/2021
IHC CD4 $  31.00 07/01/2021
IHC CD8a $  31.00 07/01/2021
IHC CD20 $  26.92 07/01/2021
IHC CD31 $  31.00 07/01/2021
IHC Cleaved Caspase-3 $  26.92 07/01/2021
IHC F4/80 $  26.92 07/01/2021
IHC GFP $  26.92 07/01/2021
IHC Ki67 $  26.92 07/01/2021
IHC Ly-6G $  26.92 07/01/2021
IHC Lyve-1 $  26.92 07/01/2021
IHC Mac2 $  26.92 07/01/2021
IHC Von Willebrand Factor $  31.00 07/01/2021
IHC Negative Control $  28.55 07/01/2021
IHC Stain, Paraffin, Other (antibody provided by PI) $  28.55 07/01/2021
IHC Stain, New Antibody Optimization Slide $  33.45 07/01/2021
IHC Stain, Frozen, Other (antibody provided by PI) $  32.63 07/01/2021
 
Special Histochemical Stains
Special Stain Gram $  28.55 07/01/2021
Special Stain Luxol Fast Blue (LFB) $  28.55 07/01/2021
Special Stain Masson Trichrome (MTC) $  16.32 07/01/2021
Special Stain Other $  28.55 07/01/2021
Special Stain Picrosirius Red (PSR) $  16.32 07/01/2021
Special Stain Prussian Blue $  24.47 07/01/2021
Special Stain Toluidine Blue $  16.32 07/01/2021
Special Stain Verhoeff Van Gieson (VVG) $  28.55 07/01/2021
Special Stain Alcian Blue (AB) $  16.32 07/01/2021
Special Stain Alcian Blue PAS (AB-PAS) $  28.55 07/01/2021
Special Stain Alizarin Red $  24.47 07/01/2021
Special Stain Congo Red $  24.47 07/01/2021
Special Stain Luxol Fast Blue PAS (LFB-PAS) $  28.55 07/01/2021
Special Stain Oil Red O (ORO) $  28.55 07/01/2021
Special Stain Periodic Acid Schiff (PAS) $  16.32 07/01/2021
Special Stain Ziehl Neelson $  28.55 07/01/2021

 

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

IVAC Clinical Pathology: Hematology, Chemistry, Diagnostic Rates*

DESCRIPTION RATE EFFECTIVE
Serum Chemistry
1 Chemistry Only/Animal $  19.80 07/01/2021
Custom Panel, 2 Chemistries/Animal $  32.18 07/01/2021
Custom Panel, 3 Chemistries/Animal $  40.83 07/01/2021
Custom Panel, 4 Chemistries/Animal $  47.61 07/01/2021
Custom Panel, 5 Chemistries/Animal $  54.00 07/01/2021
Add-on (to panel), One Chemistry $  5.67 07/01/2021
Full Chemistry Panel $  55.91 07/01/2021
Electrolytes $  19.16 07/01/2021
Mini Chem Panel $  40.87 07/01/2021
Mini Liver Panel $  22.88 07/01/2021
Pig Full Chemistry Panel $  59.87 07/01/2021
Liver Panel $  40.37 07/01/2021
Renal Panel $  29.12 07/01/2021
 
Hematology
Complete Blood Count (CBC) w/ Auto Differential $  21.30 07/01/2021
Blood Smear (prep only) $  10.76 07/01/2021
Manual (WBC) Differential $  30.42 07/01/2021
Reticulocyte Count $  30.76 07/01/2021
Hematocrit, Spun $  14.80 07/01/2021
PT/PTT $  56.64 07/01/2021
 
Other Clinical Pathology
Total Protein, Refractometer $  17.27 07/01/2021
Urinalysis, Complete $  36.08 07/01/2021
Urinalysis, Routine $  35.07 07/01/2021
Fecal Flotation $  32.26 07/01/2021
ADL Technician Labor/Hour Regular $  60.00 07/01/2021
ADL Technician Labor/Hour Overtime $  90.00 07/01/2021
Laboratory Sendout Processing Fee $  21.24 07/01/2021
Microbial Culture please inquire
Animal Pathogen PCR (panels or single) please inquire

 

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

The facilities are operated on a fee-for-service basis. Users are charged based on the amount of time technicians spend performing the services.

IVAC Aperio® Digital Slide Scanning Rates* 

DESCRIPTION RATE EFFECTIVE
Digital slide scan, Technician Labor/Hour Regular $  60.00 07/01/2021
Digital slide scan, Technician Labor/Hour Overtime $  90.00 07/01/2021
Digital slide scan, 20x, batch >50 slides, each $  6.00 07/01/2021
Digital slide scan, 20x, batch 20-50 slides, each $  8.00 07/01/2021
Digital slide scan, 20x, <20 slides, each $  10.00 07/01/2021
Digital slide scan, 40x, batch >50 slides, each $  7.00 07/01/2021
Digital slide scan, 40x, batch 20-50 slides, each $  9.00 07/01/2021
Digital slide scan, 40x, <20 slides, each $  11.00 07/01/2021

IVAC Technical Services Rates*

DESCRIPTION RATE EFFECTIVE
Technical Services Technician Labor/Hour Regular $  60.00 07/01/2021
Technical Services Technician Labor/Hour Overtime $  90.00 07/01/2021

 

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

IVAC Pathologist Rates*

DESCRIPTION RATE EFFECTIVE
IVAC Pathologist Hourly Rate $  250.00 07/01/2021

 

*Rates subject to change.

Frequently Asked Questions & Resources

Our blood sample collection guidelines can be downloaded here.

Our available chemistry panels are listed here.

Our blood sample collection guidelines can be downloaded here.

Please fill out our Sample Drop-off Appointment Request to request a day/time for drop-off.

Our board-certified veterinary pathologists are available for assistance with results interpretation. Email ULAM-IVAC@umich.edu and request pathologist interpretation.

Please inquire at ULAM-IVAC@umich.edu

IVAC Authorship/Acknowledgment Policies

To help us provide continued services, please remember to acknowledge the work of our core in your publications and presentations. We adhere to the Association of Biomolecular Resource Facilities policies on Authorship and Acknowledgment

Questions?