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Expected Adherence to Buprenorphine Dosing Changes for Mice and Rats

Expected Adherence to Buprenorphine Dosing Changes for Mice and Rats

07/01/2022 12:00 am

Icons of Buprenorphine vials with dosing interval changes and rodent silhouettes

The Guidelines on Anesthesia & Analgesia in Mice and the Guidelines on Anesthesia & Analgesia in Rats were updated in March to reflect changes to buprenorphine dosing intervals, specifically the injectable formulation(s) of buprenorphine hydrochloride, for mice and rats.

It is expected that all protocols impacted by this change will be updated no later than July 1, 2022, to align with the new guidance. After July 1, individuals who are found to be conducting procedures inconsistent with what is outlined in their IACUC approved protocol may be reported for non-compliance, pursuant to standard practices.

Please review the original announcement for more information about this change, including details on the new dosing frequency and available alternatives (including a recent update from the manufacturer of Ethiqa XR® regarding the drug’s storage and use).


Members of both the veterinary care and compliance teams are here to provide the guidance and assistance necessary for ensuring a smooth transition in your analgesic plans and can address any questions or concerns you may have about buprenorphine dosing changes.

  • For questions about drug dosing, proper analgesia, or surgical techniques, contact your ULAM Faculty Veterinarian. If you don’t know your veterinarian, send an email to and your question will be routed appropriately.
  • Questions about protocol amendments or programmatic compliance should be directed to your Quality Assurance Specialist in the Animal Care & Use Office at
Review the Full Announcement for More Information

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