Our Impact

Close up image of a cancer cell
Tuesday, September 18, 2018 Mouse Study Provides Potential Breakthrough in Defeating Cancer Stem Cells
Thanks to a new mouse study, U-M researchers have discovered why stem cells become resistant to cancer treatment and are now developing therapies to combat this resistance.
Researcher donning PPE examines mouse under flow hood
Monday, September 17, 2018 Researchers Look to Mouse Models to Gain Better Understanding of Heart Abnormalities in Patients with Dravet Syndrome
U-M researchers first looked at mouse models, and then at cells collected from children with Dravet syndrome, to identify a gene mutation that may lead to irregularities in the heart muscle’s sodium channels; irregularities that could trigger sudden unexpected death in epilepsy (SUDEP). With this important foundation in place, the research team now plans to look at different gene mutations related to SUDEP, and at the potential use of re-purposed drugs to treat Dravet syndrome and other forms of epilepsy.
Researcher donning green gloves holds small black mouse
Monday, July 30, 2018 Mice Help Researchers Uncover Intricate Cellular Process Critical to Small Intestine Development
More than 40 percent of our small intestine develops before we are even born. But problems with this process in utero can result in a rare but deadly condition known as congenital short bowel syndrome. A new Michigan Medicine study conducted with mice has helped researchers uncover the surprising sequence of cellular events responsible for proper development of the small intestine.
Lab personnel holds white rat
Monday, July 23, 2018 New Rat Study May Provide Important Clues for Outsmarting Obesity
Researchers have found that obesity-prone rats respond more strongly to food-related cues, including specific changes in cells of the same brain area linked to addiction. The model, researchers say, can be used to figure out the neural and psychological differences that drive overeating before obesity sets in — a huge step to improve obesity prevention.
Illustration depicts scarring from idiopathic pulmonary fibrosis
Monday, June 4, 2018 Mouse Model Aids in Discovery of New Treatment Options for Idiopathic Pulmonary Fibrosis
Successfully tested in mice, targeted drug and gene therapies might one day benefit patients with a deadly lung disease, new U-M research finds.
DNA HiSeq 2000 at the University of Michigan
Sunday, May 20, 2018 Common Thread Found in Mice, Humans Offers Clues for Treating Brain Dysfunction After Sepsis
U-M researchers use mouse models and 16S rRNA gene sequencing to explore the previously unstudied role of gut microbes, or microbiome, in the development of long-term cognitive impairments after sepsis infection.
Black and white mice play in mouse cage
Monday, April 30, 2018 New Platform for Delivering Cancer Treatment Shows Great Promise in Mouse Models
U-M researchers have designed a new delivery system – a drug hidden in a nanodisc – to increase the number of patients who can be treated successfully with cancer immunotherapy drugs. The novel platform for chemoimmunotherapy triggered anti-tumor immunity and eliminated colon cancer in 85 percent of treated mice.
Illustration of mouse looking at peanut
Sunday, April 15, 2018 U-M Researchers Have Developed A New Vaccine That Suppresses Peanut Allergies in Mice
After nearly two decades spent developing a vaccine agent, U-M researchers have translated this work to the development of a vaccine to treat food allergies. In their new study, the team demonstrates that this vaccine may successfully turn off peanut allergy in mice by altering the immune cell response to peanut exposure.
Dr. Robert Bartlett with a patient and family
Tuesday, April 10, 2018 Animal Model, ECMO Technology Used to Help Develop Innovative Artificial Placenta
Using an animal model, U-M researchers are making progress on an extraordinary new artificial womb technology that could one day revolutionize the care of premature infants.
Anteroposterior (AP) x-ray shows signs of non-encapsulated pulmonary cryptococcosis in a human patient infected with Cryptococcus sp. fungal organisms.
Thursday, March 15, 2018 Mouse Model Helps Researchers Examine Specific Mechanisms Underlying Cryptococcal Disease
The results obtained from this animal study may provide important guidance for the development and use of anti-inflammatory therapies to minimize central nervous system injury in patients with severe cryptococcal infections, a major source of illness in people with HIV and AIDS.