Our Impact

Image showing pipette and colorful RNA tubes
Thursday, June 11, 2020 Looking to Mouse, Macaque, and Human Germ Cells for New Insight Into Infertility
Researchers are comparing the way genes are expressed in thousands of sperm-forming cells in mice, macaques, and humans to look for similarities and differences. This comparison provides clues about how sperm has evolved in mammals.
Technician wearing PPE conducts health check on mouse in germ-free facility
Wednesday, April 15, 2020 Identical Mice, Different Gut Bacteria, Different Levels of Cancer
A study conducted using U-M's germ-free mouse facility offers new clues about how the composition of the gut microbiome may contribute to the development of colorectal cancer.
Two black mice play in enclosure with enrichment items
Thursday, April 2, 2020 Mouse Model Provides Breakthrough for Potential New Treatment of Rare Childhood Epilepsy
U-M researchers have spent years developing mouse models that would allow for testing new therapies for rare developmental and epileptic encephalopathies resulting from a single genetic mutation. Their research now suggests that SCN8A encephalopathy could be improved with a treatment already approved for other uses.
3D render of antibodies attacking virus. Photo credit: Meletios Verras, Getty Images Pro
Monday, March 23, 2020 Antiviral Compound Studied in Mice Offers Hope Against Deadly Flu
A study in mice finds that a compound modelled on a protein found in bananas safely protects against multiple strains of the influenza virus.
Senior study author Jolanta Grembecka, Ph.D., left, with co-first author Hongzhi Miao, M.S. Photo by Leisa Thompson
Monday, March 2, 2020 Anti-Leukemia Compound Induces Complete Remission in Mouse Models
An anti-cancer compound developed at the University of Michigan has shown “profound” activity in mouse models against two subtypes of leukemia — representing up to 40% of patients — a U-M research team reports in the Journal of Clinical Investigation. A Phase I clinical trial, using a structurally related analog of the compound, also began enrolling patients in the fall of 2019.
Husbandry technician holds white mouse in germ-free facility
Friday, December 13, 2019 Germ-Free Mice May Hold New Clues for Better Treatment of Iron-Related Disorders
In a study involving germ-free mice, Michigan Medicine researchers have unlocked a mechanism behind how the body decides whether or not to absorb iron from the food–one that involves the trillions of bacteria in our guts known as the gut microbiome. What these intriguing findings suggest is an unconventional treatment for iron-related disorders, such as anemia.
A potent and selective degrader of the transcription factor STAT3 offers a new approach to a previously “undruggable” target.
Friday, November 15, 2019 U-M Compound Achieves Lasting Tumor Regression of Leukemia and Lymphoma in Mouse Models
A potent and selective degrader of the transcription factor STAT3 offers a new approach to a previously “undruggable” target. In a mouse model of leukemia, the degrader eliminated all of the tumors, with the mice remaining tumor-free for 60 days. In two mouse models of lymphoma, the drug eliminated all of the tumors for more than 100 days.
White mouse climbs over bedding into clear enrichment tunnel
Friday, November 1, 2019 Discovery in Mice Could Remove Roadblock to More Insulin Production
New research published in Nature Immunology shows that a combination of two immune-system factors could open up new avenues for treating Type 1 and Type 2 diabetes and obesity.
U-M researchers studying prostate cancer cell lines
Monday, October 21, 2019 U-M-Designed Compounds Show Promise in Lab, Mouse Models of Advanced Prostate Cancer
In a new study involving mouse models and prostate cancer cell lines, University of Michigan (U-M) researchers have demonstrated the preliminary effectiveness of a new set of compounds that offer a potential advance in the treatment of metastatic castration-resistant prostate cancer — one that appears to avoid many of the usual mechanisms of treatment resistance.
Researcher looks through microscope to explore tissue regeneration
Tuesday, September 10, 2019 Interdisciplinary U-M Team Uses Mouse Models to Make Strides in Tissue Regeneration Research
Groundbreaking new research involving mouse models marries high-intensity focused ultrasound with genetically modified cells, which may spur bone and soft tissue regeneration.