Our Impact

Elderly couple sit side by side laughing while man whispers into woman's ear
Tuesday, September 27, 2022 How a Single Protein Can Slow Down Age-Related Hearing Loss
Study in mice suggests that the overexpression of cochlear neurotrophin-3 can help prevent the loss of hearing.
Image of a mouse tumor stained to show specific markers. Provided provided by Monique Verhaegen
Wednesday, September 21, 2022 Viral Proteins Key to Tumor Model in Mice
Researchers have figured out how to create a mouse model of a rare but fatal skin cancer, a scientific discovery 10 years in the making.
Credit: Danielle Dobbs/Michigan Medicine. A model demonstrating how this type of novel drug is absorbed through the lymphatic system.
Monday, September 19, 2022 New Drug Candidate Uses Novel Absorption Method to Target Cancer Cells in Mice
By using the lymphatic system as a storage reservoir, researchers found they could optimize drug concentrations to simultaneously target two molecular signaling pathways responsible for cancer growth.
Normal liver tissue (top) and a liver cancer nodule (bottom) containing many dividing cells (labeled in green). Red color indicates blood vessels. Jiandie Lin, Ph.D., University of Michigan Life Sciences Institute
Tuesday, August 23, 2022 Researchers Identify a Hormone from Fat Cells that Reprogram the Liver Microenvironment and Restrain Tumor Growth in Mice
Molecular changes in nonalcoholic fatty liver disease could serve as potential therapeutic targets to halt the cells’ progression to liver cancer.
Brown mouse in nest of brown paper bedding
Friday, July 8, 2022 Shining Light on the Link Between Lung Fibrosis and Bacterial Infection
A study in mice suggests that lung scarring could also compromise the immune system.
Collagen 1, a protein produced by tumor cells, is essential to the growth and function of these tumor oncostreams. Image courtesy of Pedro Lowenstein
Wednesday, June 29, 2022 Dynamic Cells Linked to Brain Tumor Growth and Recurrence
In mice, researchers have discovered the presence of 'oncostreams,' highly active cells connected to how brain tumors grow and invade healthy tissue.
Spoon pouring sugar into yellow coffee cup on blue background
Monday, June 6, 2022 Can a High Fructose Diet Protect Against Drug Induced Liver Damage?
A team explores the protective capabilities of consuming a diet enriched with fructose when it comes to acetaminophen overdose in mice.
Human metastatic breast cancer in the lymph nodes. National Cancer Institute – Visuals Online
Wednesday, May 11, 2022 Study Finds Nanomedicine Targeting Lymph Nodes Key to Triple Negative Breast Cancer Treatment
In mice, nanomedicine can remodel the immune microenvironment in lymph node and tumor tissue for long-term remission and lung tumor elimination in this form of metastasized breast cancer.
Caitlin O'Connor, Ph.D., is a research fellow in the Narla lab. Credit: Daryl Marshke
Friday, May 6, 2022 Mouse Model Helps Researchers Zero in on Therapeutic Target for Aggressive Uterine Cancer
A common mutation in a rare cancer subtype leads researchers to an already-approved drug that shows promise against uterine serous carcinoma.
Zhen Xu, Professor of Biomedical Engineering and Tejaswi Worlikar, Biomedical Engineering PhD student discuss the 700kHz, 260-element histotripsy ultrasound array transducer they use in Prof. Xu’s lab. Credit: Marcin Szczepanski, Michigan Engineering
Wednesday, April 20, 2022 Tumors Partially Destroyed with Sound Don’t Come Back
Technique pioneered in rats at the University of Michigan could improve outcomes for cancer and neurological conditions.

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