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Researchers Create Human Aortic Aneurysm Model to Advance Disease Understanding, Treatment Testing

When implanted into laboratory rats, the model successfully mimicked dilation of the human aorta. Using human cells in laboratory rats, Michigan Medicine researchers have developed a functional model of thoracic aortic aneurysm, creating opportunities for more effective understanding of disease development and treatments for the potentially fatal condition, a study suggests. There are currently no ...

Stem Cells Improve Memory, Reduce Inflammation in Alzheimer’s Mouse Brains

Investigators hope to advance the research to larger animals. When people think of Alzheimer’s Disease and possible treatment, amyloid — and the accumulation of plaques that invade the cerebral cortex — is often brought up first. However, scientists are finding that Alzheimer’s is influenced by many factors, including neuroinflammation and disrupted metabolism. By transplanting human ...

White lab rat in enclosure with nesting material

An Updated Rat Reference Provides More Accuracy for Research

The new genome could help researchers using rat models for the study of DNA, RNA, evolution, genes linked to disease risks. The lab rat is a classic icon of medical research, and for good reason: Since the early 1800s, scientists have relied on rats as a powerful model for discoveries related to human health and disease. Specifically, ...

Technician holds germ-free white mouse

Fiber, Genes and the Gut Microbiome: Study Reveals Possible Triggers for Inflammatory Bowel Disease

Complex interplay involving diet could explain why IBD develops. Abdominal pain, diarrhea, weight loss — these and the other symptoms of inflammatory bowel disease (IBD) can be disruptive and debilitating. And while scientists have figured out that IBD has a genetic component, not everyone with a family history develops the disease. To date, the environmental ...

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Two Genes Linked to Autism Implicated in Brain Cell Connectivity

Discovery potentially reveals mechanism behind brain changes in people with autism. Autism spectrum disorder emerges in early childhood, presenting with a broad range of signs and symptoms involving a child’s ability to communicate, learn and behave. Scientists studying autism agree that the condition likely has multiple causes, both environmental and genetic. A new U-M study links ...

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Researchers Identify Why Cancer Immunotherapy Can Cause Colitis

Studies in mice reveal the mechanism that induces this severe side effect and point to a solution that kills the cancer without causing gastrointestinal issues. Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment.  They also found a way to deliver immunotherapy’s cancer-killing impact ...

Animal technician holds white mouse in environmental enrichment tunnel

Could Ginger Help Treat Autoimmune Disease Symptoms?

After ginger root was proven to halt autoimmune disease progression in mice, researchers are now trialing the same concept in humans.

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Obesity Leads to a Complex Inflammatory Response Inside Fat Tissue

New single-cell study uncovers diverse immune cells in obese mice.

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Research Finds Potential Target for Cardiovascular Disease in Diabetes

Targeting NETs could reduce the risk of heart attack and stroke for diabetic patients.

Black mouse on reflective surface

Mouse Study Hints at Specific Brain Receptor Behind PCOS Symptoms

Advancing to the 1960s, Lorem Ipsum was made popular by typeface manufacturer Letraset, who used it in their advertising campaigns. Letraset offered pages of Lorem Ipsum as rub down transfer sheets, which were widely used in the pre-computer era for layouts.

Mouse cortex showing the nuclei of all cells (blue)

Scientists Develop New Model for Understanding Sudden Death in Epilepsy

With the mouse model, the team has identified a unique pattern in fatal seizures linked to a genetic mutation.

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Tumor-Destroying Soundwaves Receive FDA Approval for Liver Treatment in Humans

A newly developed technique provides a non-invasive alternative to surgery, chemotherapy, and radiation treatments for cancer.