Our Impact

Researcher looks at brain scans on a handheld tablet
Tuesday, June 25, 2019 Mouse Models Help Overcome Challenges to Finding Predictive Biomarkers in Rare Cancers
Using a new approach that combines data from human tumors grown in mice with data from The Cancer Genome Atlas, a team led by University of Michigan Rogel Cancer Center researchers has uncovered several previously unknown biomarkers for glioblastoma, the most common malignant brain tumor.
Monday, June 10, 2019 Why Do Women Get Autoimmune Diseases Far More Often Than Men? Transgenic Mouse Study Suggests a Root Cause and Target for New Treatments
“Many patients are frustrated that they’ve had to try multiple therapies and still nothing is working well,” Allison Billi, M.D., Ph.D., says. “To be able to tell them that we’re working on a mouse that has the same disease as them, and that we need their help, brings out their motivation and interest in research.”
Male patient receives care in the BMT Adult Clinic
Wednesday, May 29, 2019 New Research in Mice Could Lead to Better Treatment, Repair of Liver Damage
U-M researchers have discovered that the enzyme CPS1 can spur the body to prevent or repair acute liver injury in mice, which could be harnessed as a therapy or used as a biomarker to treat patients with liver damage.
Black mice play in cardboard tube
Monday, April 29, 2019 Mice Aid in Exploration of Targeted New Approach to Treat Blood Clotting in Patients with APS
A new multi-year, multi-disciplinary study examining Antiphospholipid Syndrome (APS) at the cellular level has found that two drugs reduced the development of blood clots in mice affected with the condition.
From left, Hideaki Fujiwara, M.D., Ph.D.; Grace Chen, M.D., Ph.D.; and Pavan Reddy, M.D. Photo credit: Leisa Thompson
Monday, April 1, 2019 Mice Unlock Possible Clues to Limit a Common Side Effect of Bone Marrow Transplants
In a surprising finding, researchers from the University of Michigan Rogel Cancer Center have shown that knocking out NLRP6, a protein that plays a protective role in other diseases, led to better outcomes and less-severe symptoms after bone marrow transplants in mice.
White rat looks at camera with nesting material in the background
Sunday, March 10, 2019 Monitoring Sleeping Rats May Solve Puzzle Behind Long-Term Memory Processing
To better understand the role that sleep plays in the formation of new memories, an international team of researchers designed a new study to monitor the brain activity of sleeping rats after they completed a new maze. Published in the Journal of Neuroscience, the team discovered that the process of ‘replay’ may help cellular consolidation and trigger memory transfer from the hippocampus to other brain regions.
This image depicts CDC microbiologist Valerie Albrecht, as she was holding up for observation, two Petri dish culture plates that had been inoculated with methicillin-resistant Staphylococcus aureus (MRSA) bacteria
Monday, December 17, 2018 Mice Aid in the Discovery of How Mitochondria Help Fight Life-Threatening Bacteria
Methicillin-resistant Staphylococcus aureus, also known as MRSA, has occasionally been known to cause life-threatening infections. In a study published in the journal Cell Host & Microbe, Michigan Medicine researchers share how mouse models helped them discover the important role that mitochondria play in supporting the immune system’s response against MRSA infection.
Blue DNA strand
Tuesday, November 20, 2018 Mouse Study Finds Important Link Between Immunity and Bacteria in Healthy Lungs
A new mouse study, published by U-M researchers in the American Journal of Respiratory and Critical Care Medicine, shows that bacteria in healthy lungs may play an important role in helping ward off disease.
Black mouse in clear tunnel with nesting material
Friday, October 26, 2018 Key Protein Discovered Through Mouse Models Sheds Light on Fatty Liver Origins
A new University of Michigan study in mice reveals a new role for insulin in the control of fat production.
Close up image of a cancer cell
Tuesday, September 18, 2018 Mouse Study Provides Potential Breakthrough in Defeating Cancer Stem Cells
Thanks to a new mouse study, U-M researchers have discovered why stem cells become resistant to cancer treatment and are now developing therapies to combat this resistance.