Daniel D. Myers, Jr., DVM, MPH, DACLAM
Chair, Institutional Animal Care & Use Committee (IACUC)
Dr. Myers received his DVM degree from Tuskegee University in May 1997, and completed his comparative medicine training in 2001 at the University of Michigan. He received his Masters of Public Health in hospital and molecular epidemiology in 2003 from the University of Michigan, and is also a Diplomat of the American College of Laboratory Animal Medicine. Dr. Myers has a joint appointment with the Department of Surgery and the Unit of Laboratory Animal Medicine. Currently, Dr. Myers is Director of the Conrad Jobst Vascular Research Laboratories and is nationally recognized for his expertise in translational animal model development. He is also the current chair of the Institutional Animal Care & Use Committee (IACUC), which is responsible for assessment and oversight of the institution’s Animal Care & Use Program components and facilities, including the review and approval of animal research protocols, evaluation of animal use and housing areas, monitoring and evaluation of animal use practices, review and approval of policies and standards for animal care and use, and investigation of animal welfare concerns.
Venous thromboembolism (DVT/PE) is a considerable healthcare concern in the United States, especially among the elderly. The incidence of venous thromboembolism (VTE) increases markedly with advancing age. Approximately 600, 000 non-fatal cases of VTE are reported each year, conservatively. The incidence of VTE is 2-7 times higher in those greater than 55 years of age as compared to younger aged groups, and the incidence increases 74% per decade of age over 45 years. The adhesion molecule P-selectin, which is present in platelet alpha-granules and endothelial cell Weibel-Palade bodies, is up-regulated early during thrombosis promoting vein wall inflammation in multiple animal models and humans. The receptor for P-selectin is a glycoprotein expressed on the surfaces of most hematopoietic cells termed P-selectin glycoprotein ligand-1 (PSGL-1).
This receptor is associated with adhesion interactions responsible for the initial rolling of neutrophils and platelets along stimulated vascular endothelium that initiate thrombus formation. Additionally, P-selectin: PSGL-1 interactions are responsible for thrombus amplification. There is a relationship between increased P-selecting: PSGL-1 activity, venous thrombosis, and aging. It is through these interactions during the aging process that promotes an increased risk for DVT. Studies done in our mouse model of venous thrombosis indicate that circulating P-selectin levels and thrombus burden post DVT significantly increase in older animals. Dr. Myers' research laboratory investigates why P-selectin and its prothrombotic tendencies increase with age.
To learn more about this work, please visit the Conrad Jobst Vascular Research Laboratories website.
- BS, University of California, Davis, CA
- DVM, Tuskegee University, School of Veterinary Medicine, Tuskegee, AL
Chapters in Books
- Myers, Jr. DD, Wakefield, TW. Inflammation-Dependent Thrombosis. In: Tabibzadeh S: Frontiers in Bioscience, Searingtown, New York, (www.bioscience.org/editoff.htm), 2005.
- Linn, MJ, Duran-Struuck, R, Trivedi, AK, Zajic, LB, Wrobleski, SK, Hawley, AH, Myers, Jr., DD. The Biology and Medicine of Nonhuman Primates: Part I and Part II. In: Laboratory Animal Medicine and Management, J.D. Reuter and M.A. Suckow, Eds. International Veterinary Information Service, Ithaca New York, (www.ivis.org), July 2006; B2501.0103.
- Lester P, Moore R, Shuster K, Myers DD Jr. Anesthesia and Analgesia In: The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents, M Suckow, K Stevens, R Wilson. The American College of Laboratory Animal Medicine. Academic Press, San Diego, California, January 2012.
- Lester PA, Diaz JA, Shuster KA, Henke PK, Wakefield TW, Myers DD Jr. Inflammation and thrombosis: new insights. Frontiers in Bioscience (Scholar Edition). 2012 January 1; 4:620-38.
- Myers DD, Dysko RC, Chrisp CE, Decoster JL. Subcutaneous Masses in a Rhesus Macaque (Macaca mulatta). Journal of Medical Primatology, volume 30, pg. 127-130, 2001.
- Meier T, Myers DD. Contrast Venography: A useful vein imaging methodology for nonhuman primates. Laboratory Animal Practitioner volume 37(4):18-20, 2004.
- VanLangevelde LA, Anchill SE, Wrobleski SK, Linn MJ, Wakefield TW, Myers, Jr., DD. Gender Differences of Deep Venous Thrombosis in a Rat Model: A preliminary study. Comparative Medicine, volume 55(1):44-49, 2004.
- Meier TR, Myers DD, Eaton KA, Ko MC, Hankenson FC. Gangrenous Clostridium perfringens Infection and Subsequent Wound Management in a Rhesus Macaque. The Journal of the American Association of Laboratory Animal Science, volume 46(3): 69-73, 2007.
- Alvarado CM, Diaz JA, Hawley AE, Wrobleski SK, Sigler RE, Myers DD Jr. Male mice have increased thrombotic potential: Sex differences in a mouse model of venous thrombosis. Thrombosis Research. 2011 May; 127(5):478-86. Epub 2011 February 5.
- Wrobleski SK, Farris DM, Diaz JA, Myers DD Jr., Wakefield TW. Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis. Journal of Visualized Experiments. 2011 June 12 ;( 52). pii: 2738. doi: 10.3791/2738.
- Diaz JA, Wrobleski SK, Hawley AE, Lucchesi BR, Wakefield TW, Myers DD Jr. Electrolytic Inferior Vena Cava Model (EIM) of Venous Thrombosis. Journal of Visualized Experiments. 2011 July 12 ;( 53). pii: 2737. doi: 10.3791/2737.
- Hampton AL, Diaz JA, Hawley AE, Wrobleski SK, Wang JG, Lee RD, Kirchhofer D, Sigler RE, Wakefield TW, Mackman N, Myers DD Jr. Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model. Thrombosis Research 2011 December 20; [Epub ahead of print].
- Diaz JA, Obi AT, Myers DD Jr., Wrobleski SK, Henke PK, Mackman N, Wakefield TW. Critical review of mouse models of venous thrombosis. Arteriosclerosis Thrombosis and Vascular Biology. 2012 Mar; 32(3):556-62.
- Diaz JA, Ballard-Lipka NE, Farris DM, Hawley AE, Wrobleski SK, Myers DD Jr., Henke, PK, Lawrence DA, Wakefield TW. Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. Journal of Vascular Surgery 2012; 55:815-822.
- Myers DD Jr. Nonhuman primate models of thrombosis. Thrombosis Research. 2012 May; 129 Suppl 2:S65-9.
- Culmer DL, Diaz JD, Hawley AE, Jackson TO, Shuster K, Sigler RE, Wakefield TW, Myers DD Jr. Circulating and vein wall p-selectin promote venous thrombogenesis during aging in a rodent model. Thrombosis Research. 2012 Nov 20. doi:pii: S0049-3848(12)00796-7. [Epub ahead of print]
- Patterson KA, Zhang X, Wrobleski SK, Hawley AE, Lawrence DA, Wakefield TW, Myers DD, Diaz JA. Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects. Thromb Res. 2012 Dec 28. doi:pii: S0049-3848(12)00882-1. [Epub ahead of print]
- Thomas Meier, DVM, DACLAM (2008, DACLAM, Foster Award Winner)
- Rashida Moore, DVM, DACLAM (2010, DACLAM)
- Patrick Lester, RPH, DVM, MS, BCPS (2011, DACLAM, Foster Award Winner)
- Christine Alvarado, DVM (Board Eligible, Sitting for 2013 Exam)
- Anna Hampton, DVM, DACLAM (2012, DACLAM)
- Asheley Wathen, DVM, DACLAM (2012, DACLAM)
- Dorian Culmer, DVM (Board Eligible, Sitting for 2013 Exam)
- Katherine Shuster, DVM (Board Eligible, Sitting for 2013 Exam)
- Kathleen Patterson, DVM (Board Eligible, Sitting for 2013 Exam)
- Gerald A. Hish, Jr., DVM (Post-doctoral Research Fellow, 2012 to present)