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Drugs Facilities Guidelines Husbandry IACUC Policies Safety

Lessons Learned from Fall 2024 Semi-Annual Facility Inspections

The Institutional Animal Care & Use Committee (IACUC) completed its latest round of semi-annual facility inspections in late September, which included piloting a new one-week condensed schedule. This revised format more closely aligns IACUC processes with those used by external oversight bodies (e.g., AAALAC and the United States Department of Agriculture) and aims to reduce ...
Multi-colored graph showing common deficiency areas identified during Fall 2024 semi-annual facility inspections

Drugs ULAM

Update on Nationwide IV Fluid Shortage

As you may be aware, Baxter IV Solutions, a main supplier of Michigan Medicine’s IV products, was heavily impacted by the recent hurricane in North Carolina. In the coming weeks, it is expected that large volume IV fluids/irrigation ranging from 250mL to 5000mL will be in short supply in human clinical patient settings nationwide. This ...
Picture of IV fluid bags with information icon that says Supply Shortage What to Know

Drugs Guidelines Policies

Additional Tools to Support the Responsible Use of Drugs, Substances, and Other Agents in Animal Studies

The Animal Care & Use Program has created three new tools to assist the U-M research community with navigating the many nuanced requirements for the proper administration and use of medical materials, drugs, agents, and other substances in animal studies: These tools are designed to complement existing resources such as the Quick Reference Sheet: Monitoring ...
Navigating the proper use of substances and agents with animals decision tree icon

Controlled Substances Drugs Guidelines IACUC Policies

Revised Policies, Guidelines Clarify Expectations for the Use of Expired Drugs and Medical Materials in Animals

We know that you rely on us – your Animal Care & Use Program partners – to provide the tools and resources necessary for safeguarding animal welfare while conducting sound scientific research. While it is clear that the administration and/or use of expired drugs and other substances can endanger animal health and compromise the validity ...
Picture of veterinary drugs and materials clearly labeled with expiration dates

Drugs ULAM

Ethiqa XR® Broached Vial Usage Extended to 90 Days

Fidelis Pharmaceuticals, the company that produces Ethiqa XR®, the first FDA-indexed extended-release buprenorphine formulation specifically for mice and rats, recently announced a change to the drug’s storage requirements. After extensive in-house studies and testing to collect sufficient efficacy data, the company has extended the drug’s storage and use to 90 days post vial broach. Previously, ...
Medicine vial labeled with 90 day expiration sticker

Controlled Substances Drugs

Update on Ongoing Nationwide Ketamine Shortage

**December 2023 Update** The Central B2 Pharmacy has ended its Ketamine order restriction for research studies – including all projects involving animals. Study Teams may also continue to purchase Ketamine through U-M approved external vendors. If you have any questions, please contact the U-M Controlled Substances Monitoring Program at [email protected] A nationwide shortage of the ...
Vial of Ketamine Hydrochloride with Update Banner

Drugs

Urgent Notice: Standard Xyzaline Concentration No Longer Available

We have recently learned that the standard concentration of xylazine (20 mg/ml x 20 ml vial – Ana-Sed) used by many U-M laboratories for sedation/anesthesia is no longer available. This specific formulation was manufactured by a supplier (Akorn Pharmaceuticals) that has recently gone out of business and, as such, the product has been discontinued. Currently, there ...
Vial of 20mg/ml Xylazine with urgent warning icon

Controlled Substances Drugs Guidelines IACUC Policies

New Resources to Promote Responsible Use of Drugs and Other Medical Materials

The appropriate use of drugs and other medical materials – fluids, vehicles, biologics, and drugs – is critical for protecting animal welfare, ensuring the validity of your results, and avoiding incidents of non-compliance. Given the seriousness of these concerns, recent updates to several programmatic documents, and an analysis of areas identified for continued refinement through ...
NEW banner with medical materials and drugs icons

Controlled Substances Drugs

Ordering Ketamine for Use in Animals

Recently, shortages of the anesthetic drug Ketamine have been reported in human medicine. Thus far, supplies manufactured specifically for use in veterinary animal care have NOT been impacted. As a result of shortages in the human drug, the Michigan Medicine B2 Pharmacy is currently limiting the distribution of Ketamine to animal users. Study Teams needing ...
Notice icon about human drug shortages of Ketamine that may impact animal users