Drugs

Controlled Substances Drugs

Controlled Substances Security Reminder

If your laboratory stores controlled substances in a safe with a battery-operated electronic keypad, please review the following recommendations from U-M’s Controlled Substances (CS) in Research Monitoring Program to help prevent lockouts and maintain reliable access: Questions? Additional questions or concerns regarding the use of controlled substances in research, including requirements for safe and secure ...
Safe and batteries icon

Drugs

Important Notice: Buprenorphine Recall

We have recently learned of a recall issued by Par Health for specific lots of Buprenorphine Injection 0.3mg/mL, 1mL (details outlined in the table below). This voluntary recall was initiated due to the potential for the presence of white, crystalline product particulates which are comprised of the drug product formulation, principally Buprenorphine free base. These ...
Notice banner text with illustrated Buprenorphine Injection 0.3mg/mL, 1mL icon

Drugs Guidelines Policies

Drug Labeling Simplified: New Printable Template & Essential Reminders

The proper storage and use of drugs and other medical materials in animal-based research – including clear and appropriate labeling of all substances – is essential for ensuring animal welfare, maintaining programmatic compliance, and protecting scientific rigor. To assist laboratories with this simple but important task, our Program has developed a standard labeling template that ...
Medicine vial icons with Beyond Use Date label

Drugs Facilities Guidelines Husbandry IACUC Policies Safety

Lessons Learned from Fall 2025 Semi-Annual Facility Inspections

The Institutional Animal Care & Use Committee (IACUC) completed its latest round of semi-annual facility inspections in September. These routine inspections are one of the most important tools we have for assessing programmatic strengths and identifying areas for individual and collective improvement(s) in service to the animals entrusted to our care. Through this lens of ...
Multi-colored graph showing common deficiency areas identified during Fall 2025 semi-annual facility inspections

Drugs Federal Regulations & Standards Guidelines Policies ULAM

A Visual Guide to Finding Beyond Use Dates on Drug Packaging

Many pharmaceutical products used in animal-based research have a standard “Expiration Date” as well as a “Use-By-Date” (i.e., “Beyond Use Date”). These dates are generally included on the package insert or vial and can often be found under the headings “Storage,” “Storage Instructions,” or “Dosage and Administration.” Some products that are formulated by multiple manufacturers ...
Enrosite vial and packaging labeled with Beyond Use Date

Drugs Facilities Guidelines Husbandry IACUC Policies Safety

Lessons Learned from Winter 2025 Semi-Annual Facility Inspections

The Institutional Animal Care & Use Committee (IACUC) completed its latest round of semi-annual facility inspections in mid-March. These routine inspections are one of the most important tools we have for assessing programmatic strengths and identifying areas for individual and collective improvement(s) in service to the animals entrusted to our care. Through this lens of ...
Multi-colored graph showing common deficiency areas identified during Winter 2025 semi-annual facility inspections

Drugs Federal Regulations & Standards Guidelines Policies ULAM

Additional Guidance & Resources for Managing Products with Beyond Use Dates

Navigating the many nuanced requirements for the proper management, storage, and maintenance of drugs, agents, and other substances used in animal-based research can be challenging and confusing, especially when these supplies are dated. Many pharmaceutical products have both a standard “Expiration Date” and a “Use-By-Date” (i.e., “Beyond Use Date”), which are often described in the ...
Image of vials being picked up by person with gloved hand

Drugs Facilities Guidelines Husbandry IACUC Policies Safety

Lessons Learned from Fall 2024 Semi-Annual Facility Inspections

The Institutional Animal Care & Use Committee (IACUC) completed its latest round of semi-annual facility inspections in late September, which included piloting a new one-week condensed schedule. This revised format more closely aligns IACUC processes with those used by external oversight bodies (e.g., AAALAC and the United States Department of Agriculture) and aims to reduce ...
Multi-colored graph showing common deficiency areas identified during Fall 2024 semi-annual facility inspections

Drugs ULAM

Update on Nationwide IV Fluid Shortage

As you may be aware, Baxter IV Solutions, a main supplier of Michigan Medicine’s IV products, was heavily impacted by the recent hurricane in North Carolina. In the coming weeks, it is expected that large volume IV fluids/irrigation ranging from 250mL to 5000mL will be in short supply in human clinical patient settings nationwide. This ...
Picture of IV fluid bags with information icon that says Supply Shortage What to Know