Our Impact

Researcher holding brown mouse
Wednesday, April 26, 2017 New Mouse Model Aims to Find Novel Therapies to Prevent Chronic Lung Transplant Rejection
A team of U-M researchers has developed a novel mouse lung transplant model of chronic rejection to test if two new therapeutic treatments would decrease the scarring process in lung transplant patients.
Researcher examines white germ-free mouse
Wednesday, April 26, 2017 New Mice Study Shows Gut Bacteria May Protect Newborns Against Infections
Why do so many babies fall victim to infections that invade the gut but others don't? Research in germ-free mice yields important clues.
Researcher holding black mouse
Tuesday, February 28, 2017 Germ-Free Mice Study Shows Importance of High-Fiber Diet in Protecting Against Infection
Using U-M's germ-free mouse facility and advanced genetic techniques, an international team of researchers studied the impact of diets with different fiber content -- and those with no fiber. The findings show the importance of eating natural fiber to protect the digestive tract's vital mucus barrier.
Researcher donning personal protective equipment holds small black mouse
Sunday, February 5, 2017 New Mouse Model Leads to a Surprising Discovery that Sheds Light on Metaplastic Breast Cancer
For more than a decade, Celina Kleer, M.D., Harold A. Oberman Collegiate Professor of Pathology and director of the Breast Pathology Program at the U-M Cancer Center, has been studying how a poorly understood protein called CCN6 affects breast cancer. To learn more about its role in breast cancer development, Kleer's lab designed a special mouse model that deleted CCN6 from the mammary gland in mice, which allowed the team to study effects specific to the loss of the protein. The results, recently published in Oncogene, have revealed a key genetic driver for a rare form of metaplastic breast cancer.
Rats being studied in laboratory
Monday, December 12, 2016 U-M Researchers Share Rat Model with Scholars Worldwide
It's a pretty obvious connection - those who exercise more often are less susceptible to disease. But how exactly does a man’s aerobic capacity affect his chances of suffering a spontaneous heart attack? And how does a woman’s running ability impact her brain function? U-M researchers have developed a unique rat model that provides scientists worldwide with a significant resource to study how exercise endurance capacity correlates with disease risks.
White rat being held by laboratory animal technician
Monday, December 12, 2016 Genetic Markers That Influence Addiction Discovered in Rat Study
Who gets hooked on drugs and who stays clean? New research, conducted in rats, identifies genetic markers that influence addiction.
Images of an MRI brain scan
Monday, December 12, 2016 Novel Mouse Model Offers Hope for Fighting Children's Brain Tumors
Children with brain tumors have had limited treatment options in the past compared with adults. A novel research model, developed in mice at U-M, will make it easier and faster to test new treatments.
Dr. Robert Bartlett holds ECMO medical device
Friday, December 9, 2016 Life-Saving ECMO Device Made Possible By Sheep Research
It was thought to be strange and risky in the 1970s, but research with sheep paved the way to a new machine that gave critically-ill patients with failing hearts and lungs a chance for their organs to rest and repair themselves. To date: 50,000 patients treated; more than 2,000 of them right here at U-M, and thousands of lives saved.
Pink zebrafish in fish tank
Friday, December 9, 2016 Regenerative Properties of Zebrafish Used for Treating Blinding Eye Diseases
U-M researchers are using the regenerative properties of zebrafish to develop novel strategies for treating blinding eye diseases.
illustration showing human pancreas
Friday, December 9, 2016 Mouse Study Shines a Light on Pancreatic Insulin
Scientists and doctors have long wanted to know how much insulin a person has, but haven't been able to know the exact amount without physically removing the pancreas from a deceased patient for review. But a new study in the journal Diabetes details how a group of researchers was finally able to visualize stored insulin in the pancreas of a living creature -- in this case, a mouse.